Publications by authors named "Kasia Goljanek-Whysall"
In the quest of identifying newer molecular targets for the management of glucocorticoid-induced ocular hypertension (GC-OHT) and glaucoma (GCG), several microarray studies have attempted to investigate the genome-wide transcriptome profiling of primary human trabecular meshwork (TM) cells in response to dexamethasone (DEX). However, no studies are reported so far to demonstrate the temporal changes in the expression of genes in the cultured human TM cells in response to DEX treatment. Therefore, in the present study, the time-dependent changes in the genome-wide expression of genes in primary human TM cells after short (16 hours: 16 h) and long exposure (7 days: 7 d) of DEX was investigated using RNA sequencing.
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- Osteoarthritis is the most common joint disorder, marked by the breakdown of articular cartilage, but effective treatments remain elusive.
- This study aimed to identify key genes and micro-RNAs linked to osteoarthritis through a systematic meta-analysis of gene expression in affected cartilage.
- The research identified an enriched pathway related to cellular senescence and constructed a comprehensive network of 1,689 genes, leading to the discovery of five new proteins associated with osteoarthritis that could be potential targets for future treatments.