A validated chiral chromatographic method for the enantiomeric separation of acalabrutinib.

Acalabrutinib is aided in the treatment of various cancers, which acts by inhibiting Bruton tyrosine kinase. Acalabrutinib belongs to the imidazopyrazine class consisting of a chiral carbon, resulting in two enantiomers. Currently, no methods exist for the separation and quantification of these enantiomers.

Inflammatory bowel disease.

Crohn disease and ulcerative colitis are the most common forms of inflammatory bowel disease (IBD) likely to be encountered in primary care. Patient-centered care is essential for positive outcomes, and should include long-term continuity with an empathetic primary care provider who can provide skillful coordination of the requisite multidisciplinary approach. Early suspicion of the diagnosis and referral to expert gastroenterologists for confirmation and medical management is essential.

The impact of post-infectious functional gastrointestinal disorders and symptoms on the health-related quality of life of US military personnel returning from deployment to the Middle East.

Background And Aim: Mental and physical health-related quality of life (HRQOL) are important health impact measures following military deployment. While conditions such as post-traumatic stress disorder (PTSD) are known to adversely affect QOL, little is known about the effect of post-infectious functional gastrointestinal disorders (PI-FGID). Our aim was to evaluate the risk of PI-FGID and its impact on HRQOL among military personnel returning from deployment.

Provider Link: facilitating healthcare providers' support of web-based smoking cessation efforts via secure e-mail.

Provider Link is a system designed to enhance the efficacy of a web-based intervention for smoking cessation by helping health care providers support their patients via e-mail. The system is designed to maintain confidentiality while allowing providers rapid access to patient data collected over the web. A trial of Provider Link is currently underway.