Publications by authors named "Kashvi C Shah"
Article Synopsis
- DAB2 protein is often found in 80-90% of tumors, including breast cancer, and is considered a potential tumor suppressor, though it may also enhance tumor growth and drug resistance by interacting with the Ras/MAPK pathway.
- This protein is typically under-regulated in various cancers and has functions in modulating mechanisms of cancer development, such as promoting cell death and inhibiting cell proliferation through TGF-β mediated endocytosis.
- The review discusses DAB2's role in breast cancer progression and suggests that increasing DAB2 levels could be a new therapeutic strategy for treating breast cancer and potentially other diseases.
A multifunctional scaffold protein termed Disabled-2 (Dab2) has recently gained attention in the scientific community and has emerged as a promising candidate in the realm of cancer research. Dab2 protein is involved in a variety of signaling pathways, due to which its significance in the pathogenesis of several carcinomas has drawn considerable attention. Dab2 is essential for controlling the advancement of cancer because it engages in essential signaling pathways such as the Wnt/β-catenin, epidermal growth factor receptor (EGFR), and transforming growth factor-beta (TGF-β) pathways.
View Article and Find Full Text PDFSARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths worldwide and poses significant challenges. Researchers have recently studied a new antiviral drug called molnupiravir for treating COVID-19. This review examines the causes and immunopathogenesis of COVID-19, as well as the role of molnupiravir in its treatment.
View Article and Find Full Text PDFBackground: Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases. Antiepileptic drug-induced involuntary movements have been well researched.
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- * Nogo proteins, particularly Nogo-A, play a significant role in neurological diseases by inhibiting axonal regeneration in the central nervous system (CNS), while other isoforms (Nogo-B and Nogo-C) are linked to different health issues.
- * Recent studies suggest that targeting Nogo-A could have therapeutic potential in treating neurodegenerative diseases, but further research is needed to understand the full effects of Nogo proteins in the CNS.
Type-2 diabetes mellitus (T2DM) is a chronic immuno-inflammatory and metabolic disease characterized by hyperglycemia and insulin resistance with corresponding hyperinsulinemia. On the other hand, Alzheimer's disease (AD) is a neurodegenerative disease involving cognitive impairment, neuronal dysfunction, and memory loss. Several recently published literatures suggest a causal relationship between T2DM and AD.
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