Publications by authors named "Kashuai Lin"
KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Cancer Commun (Lond)
September 2021
Article Synopsis
- Histone deacetylases (HDACs) are crucial in regulating gene expression, and their dysregulation can lead to cancer, making them important targets for treatment, although HDAC inhibitors alone have had limited success in solid tumors.
- This study aimed to find a new downstream target of HDACs to improve combination therapy outcomes by analyzing breast cancer cells for gene responsiveness to HDAC inhibitors using various methods, including transcriptome sequencing and flow cytometry.
- The research identified KDELR2 as a novel target of HDAC3, linking its expression to poor breast cancer prognosis and demonstrating that the HDAC3-KDELR2 pathway enhances cancer cell proliferation and tumor growth by stabilizing the centrosomal protein POC5.
Introduction: Previous studies of coronavirus disease 2019 (COVID-19) have focused on the general population. However, diabetes (DM) as one of the most common comorbidities is rarely studied in detail. This study is aimed at describing clinical characteristics and determining risk factors of ICU admission for COVID-19 patients with DM.
View Article and Find Full Text PDF