[Endocytosis by liver cells during stimulation of the mononuclear phagocyte system by yeast polysaccharides].

Endocytosis (phagocytosis, fluid-phase- and receptor-mediated endocytosis) by liver cells, lysosomal enzyme activities have been studied during macrophages stimulation by yeast polysaccharides. It was shown that like macrophages stimulator zymosan, yeast polysaccharides cryelan and rhodexman increased the carbon particles phagocytosis. The most effective was intravenous administration of yeast polysaccharides.

[Effect of yeast polysaccharides on the functional activity of macrophages in white mice].

It was shown that the effect of polysaccharides such as hetero- and homoglycans, polyuronides and neutral polysaccharides on the functional status of macrophages was different by the activation level. The activity of the polysaccharides depended on the charge and polymeric properties of the molecules, glycoside bond configuration and supermolecular structure.

[Effect of a deficiency in the mononuclear phagocyte system and the administration of yeast polysaccharide on the development of a heterotopic source of hematopoiesis].

Mononuclear phagocyte system (MPS) deficiency was induced by repeated peritoneal lavage in (C57Bl x CBA) F1 mice. The animals were then used as donors or recipients in heterotopic bone marrow transplantation. Yeast polysaccharide (YP) produced by Cryptococcus luteolus strain 228 was injected weekly (25 mg/kg) during 30 days after bone marrow transplantation under the kidney capsule.

[Formation of a heterotopic hemopoiesis focus from the administration of a cryptococcal heteropolysaccharide to bone marrow donors and recipients].

The effect of Cryptococcus luteolus (strain 228) heteropolysaccharide on heterotopic bone marrow organ formation was studied. Heteropolysaccharide (Hp) injections were initiated on the next day after bone marrow transplantation and were performed weekly for 30 days. This resulted in the increase in both the cellularity and the weight of the ossicle.

[Macrophage activation by polysaccharides from yeast-like fungi].

The effect of polysaccharides isolated from yeast-like fungi on diverse activities of murine peritoneal macrophages was studied in experiments in vitro. Yeast polysaccharides had a nonspecific activating effect on macrophages in tissue culture. They enhance the adhesion of macrophages to glass, stimulate phagocytosis and intracellular digestion, and change the chemotactic activity.

[Possibilities of using fungal polysaccharides as the stimulants of accumulation of antibody-producing cells].

A study was made of the influence of yeast polysaccharides of definite structure and mol wt on the accumulation of anitbody forming cells (AFC) in the spleen of mice belonging to different strains. Yeast mannans Rh. rubra and Sp.