Publications by authors named "Kashif Sardar Bangash"
Article Synopsis
- This study investigates how changes in DNA repair genes may influence the risk of developing urothelial bladder carcinoma (UBC), revealing significant associations with specific gene polymorphisms.
- Researchers genotyped a group of 200 UBC patients and 200 controls, finding that OGG1 rs2304277 and XPC rs2228001 are linked to a higher likelihood of developing the disease.
- The findings suggest increased risks for both smokers and nonsmokers, as well as for different tumor grades, highlighting the significance of these genetic variants in UBC susceptibility, particularly in the Pakistani population.
Urothelial bladder carcinoma (UBC) is the most common among urinary bladder neoplasms. We carried out a preliminary study to determine the genetic etiology of UBC in Pakistani population, for this 25 sequence variants from 17 candidate genes were studied in 400 individuals by using polymerase chain reaction-based techniques. Multivariate logistic regression analysis was performed for association analysis of the overall data as well as the data stratified by smoking status, tumor grade and tumor stage.
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