Triterpenoids from Frankincense and Boswellia: A focus on their pharmacology and C-NMR assignments.

Here we report for the first time the entire C-NMR spectral assignments of 119 (out of 127) triterpenoids from the oleo-gum resins of the medicinally important genus Boswellia, which includes the culturally highly valuable Frankincense species. The complete C-NMR resonances of these triterpenoids isolated between 1998 and 2024 and their biological activities are presented. C-NMR spectroscopy is a highly powerful tool for the characterization of these bioactive natural products.

Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors.

Carbonic anhydrase-II (CA-II) is strongly related with gastric, glaucoma, tumors, malignant brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. With an aim to develop novel heterocyclic hybrids as potent enzyme inhibitors, we synthesized a series of twelve novel 3-phenyl-β-alanine 1,3,4-oxadiazole hybrids (-), characterized by H- and C-NMR with the support of HRESIMS, and evaluated for their inhibitory activity against CA-II. The CA-II inhibition results clearly indicated that the 3-phenyl-β-alanine 1,3,4-oxadiazole derivatives - exhibited selective inhibition against CA-II.

Antiproliferative and Carbonic Anhydrase II Inhibitory Potential of Chemical Constituents from and : Evidence from In Silico Target Fishing and In Vitro Testing.

Roem. & Schult and resin of (L.) BURM.

Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from with Structure-Activity Relationship: In Vitro and In Silico Studies.

Fourteen triterpene acids, viz., three tirucallane-type (-), eight ursane-type (-), two oleanane-type (, ) and one lupane type (), along with boswellic aldehyde (), α-amyrine (), epi-amyrine (), straight chain acid (), sesquiterpene () and two cembrane-type diterpenes (, ) were isolated, first time, from the methanol extract of resin. Compound () was isolated for first time as a natural product, while the remaining compounds (‒) were reported for first time from The structures of all compounds were confirmed by advanced spectroscopic techniques including mass spectrometry and also by comparison with the reported literature.

α-Glucosidase Inhibition and Molecular Docking Studies of Natural Brominated Metabolites from Marine Macro Brown Alga .

Bioassay guided isolation of the methanolic extract of marine macro brown alga afforded one new metabolite (ethyl methyl 2-bromobenzene 1,4-dioate, ), one new natural metabolite (diethyl-2-bromobenzene 1,4-dioate, ) along with six known metabolites (-) reported for the first time from this source. The structure elucidation of all these compounds was achieved by extensive spectroscopic techniques including 1D (H and C) and 2D (NOESY, COSY, HMBC and HSQC) NMR and mass spectrometry and comparison of the spectral data of known compounds with those reported in literature. The in vitro α-glucosidase inhibition studies confirmed compound to be the most active against α-glucosidase enzyme with IC value of 30.