Levofloxacin induces erythrocyte contraction leading to red cell death.

Background: Levofloxacin, a fluoroquinolone, is an extensively used antibiotic effective against both positively and negatively staining bacteria. It works by inhibiting bacterial topoisomerase type II and topoisomerase type IV, resulting in impaired DNA synthesis and bacterial cell death. Eryptosis is another term for apoptotic cell death of erythrocyte marked by cell shrinkage, phosphatidylserine (PS) flipping, and membrane blebbing.

NiO/MnFeO Nanocomposite Photoluminescence, Structural, Morphological, Magnetic, and Optical Properties: Photocatalytic Removal of Cresol Red under Visible Light Irradiation.

In this study, pure nickel oxide (NiO), manganese ferrite (MnFeO or MFO), and binary nickel oxide/manganese ferrite (NiO/MFO1-4) nanocomposites (NCs) were synthesized using the Sol-Gel method. A comprehensive investigation into their photoluminescence, structural, morphological, magnetic, optical, and photocatalytic properties was conducted. Raman analysis, UV-Vis spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction techniques were used to characterize the materials.

Antibacterial, Antibiofilm, and Anti-Quorum Sensing Potential of Novel Synthetic Compounds Against Pathogenic Bacteria Isolated From Chronic Sinusitis Patients.

Quorum sensing (QS) is a major controller of virulence and biofilm formation in pathogenic bacteria. The aim of the research was to screen novel synthetic compounds (18) from 2 series (Pyrazole and Diene dione) for quorum sensing and biofilm inhibitory potential against resistant pathogens isolated from patients with chronic sinusitis. Most of the compounds have documented zone of inhibition against Gram positive strains , and moderate activity against Gram negative and in comparison with standard antibiotic.

Pathogenic role of cytokines in COVID-19, its association with contributing co-morbidities and possible therapeutic regimens.

The Covid-19, a threatening pandemic, was originated from China in December 2019 and spread quickly to all over the world. The pathogenesis of coronavirus is linked with the disproportionate response of the immune system. This involves the systemic inflammatory reaction which is characterized by marked pro-inflammatory cytokine release commonly known as cytokine release storm (CRS).

Induction of Erythrocyte Membrane Blebbing by Methotrexate-Induced Oxidative Stress.

Methotrexate (MTX) is a common chemotherapeutical agent and folate antagonist with reported apoptotic activity in nucleated cells. The presented research work was planned to investigate the eryptotic effects of methotrexate after the exposure of erythrocytes to therapeutical doses (10-15 μM) of methotrexate. Eryptosis and the role of calcium in the stimulation of membrane blebbing were evaluated through the determination of mean cell volume.

The electrochemical, dielectric, and ferroelectric properties of Gd and Fe doped LaNiO with an efficient solar-light driven catalytic activity to oxidize malachite green dye.

This work investigates the effects of double ion substitution on the ferroelectric, electrochemical, dielectric and photocatalytic properties of Gd and Fe doped LaGdNiFeO nanoparticles (NPs). LaGdNiFeO was fabricated by facile micro-emulsion path and its properties were studied by thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman scattering, Fourier Transform of Infrared (FTIR), energy dispersive x-rays (EDX) techniques. It has a distorted rhombohedral shape with crystallite size within the range of 17-23 nm.

Induction of Erythrocyte Shrinkage by Omeprazole.

Omeprazole, a proton pump inhibitor blocks the H/K-ATPase channels of gastric parietal cells. It is used for the treatment of peptic ulcer. Prolonged use of omeprazole may involve in inducing anemia.

Cu nanoparticles synthesis using biological molecule of P. granatum seeds extract as reducing and capping agent: Growth mechanism and photo-catalytic activity.

In view of extended applications of nanoparticles, the nanoparticles synthesis is an extensive research field and green synthesis is one of the co-friendly methodologies. Plant extract mediated synthesis of nanoparticles has gained much attention in current decade. In current investigation, copper nanoparticles (CuNPs) were prepared using P.

Nickel nanoparticle synthesis using Camellia Sinensis as reducing and capping agent: Growth mechanism and photo-catalytic activity evaluation.

Recently, the biosynthesis of nanoparticle attracted the attention of scientific community due to its simplicity, ease and eco-friendly nature. In the present study, Camellia Sinensis (C. Sinensis) leaves extract was employed for the synthesis of nickel nanoparticles (NiNPs).

The Role of Janus Kinase 3 in the Regulation of Na⁺/K⁺ ATPase under Energy Depletion.

Background/aims: Janus kinase-3 (JAK3) is activated during energy depletion. Energy-consuming pumps include the Na(+)/K(+)-ATPase. The present study explored whether JAK3 regulates Na(+)/K(+)-ATPase in dendritic cells (DCs).

Piperlongumine-induced phosphatidylserine translocation in the erythrocyte membrane.

Background: Piperlongumine, a component of Piper longum fruit, is considered as a treatment for malignancy. It is effective by inducing apoptosis. Mechanisms involved in the apoptotic action of piperlongumine include oxidative stress and activation of p38 kinase.

Upregulation of excitatory amino acid transporters by coexpression of Janus kinase 3.

Janus kinase 3 (JAK3) contributes to cytokine receptor signaling, confers cell survival and stimulates cell proliferation. The gain of function mutation JAK3(A572V) is found in acute megakaryoplastic leukemia. Replacement of ATP coordinating lysine by alanine yields inactive JAK3(K855A).