Publications by authors named "Kasey Skinner"
Diffuse midline glioma (DMG) is a leading cause of brain tumor death in children. In addition to hallmark H3.3K27M mutations, significant subsets also harbor alterations of other genes, such as and .
View Article and Find Full Text PDFThe Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal neoplasm glioblastoma (GBM) that through a series of negative clinical trials has prompted a vocal subset of the neuro-oncology community to declare this target dead. However, an argument can be made that the core tenets of precision oncology were overlooked in the initial clinical enthusiasm over EGFR as a therapeutic target in GBM.
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- Metastatic urothelial carcinoma, a type of bladder cancer, is tough to cure with current treatments.
- Many mutations affect how genes are turned on and off, especially in a gene called ARID1A, which is missing or broken in about 20% of these cancers.
- Research has shown that cancers with ARID1A mutations respond better to drugs that block another gene called EZH2, especially when used together with PI3K inhibitors.
Article Synopsis
- Glioblastoma (GBM) is a common and aggressive brain tumor with poor prognosis, and specific mutations in the PIK3CA gene are believed to play a crucial role in tumor growth and reaction to treatment.
- Researchers examined the effects of PIK3CA mutations in both normal human astrocytes and mouse models to understand their role in gliomagenesis and treatment response using targeted inhibitors.
- Findings showed that specific mutations in the PIK3CA gene influence tumor formation differently; while they didn't affect sensitivity to single inhibitors, mutations in the helical domain enhanced the effectiveness of combined PI3K and MEK inhibitors, suggesting a potential targeted therapy approach for patients with these mutations.
Here, the application of the fluorinated polymer [Dupont AF, a copolymer of 4,5-difluoro-2,2-bis(trifluoromethyl)-1,3-dioxole and tetrafluoroethylene] is described in stabilizing phosphonate-derivatized molecular assemblies on oxide electrodes. In the procedure, the polymer was dip-coated onto the surfaces of oxide electrodes with pre-bound, phosphonate-derivatized chromophores and assemblies, including assemblies for water oxidation. The results of the experiments showed a high degree of stabilization by the added polymer and a demonstration of its use in stabilizing surface-bound assemblies for water-oxidation catalysis.
View Article and Find Full Text PDFBackground: Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Prognosis remains poor despite multimodal therapy. Developing alternative treatments is essential.
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