Publications by authors named "Kasey Greathouse"
Article Synopsis
- - The study focused on the impact of an evidence-based sedation bundle for ICU patients requiring mechanical ventilation during the early phase of the COVID-19 pandemic, addressing the challenges posed by increased patient volumes.
- - Researchers implemented the sedation bundle using structured training and feedback, aiming to encourage goal-directed sedation to prevent excessive use of sedatives among critically ill COVID-19 patients.
- - A comparison of sedative use and clinical outcomes was made between patients admitted before and after the bundle implementation, revealing increased use of benzodiazepines and changes in patient care metrics.
Background: Postoperative neurosurgical patients have increased risk of seizures. Traditional anti-epileptics, such as phenytoin, are not always effective and cause adverse effects. Levetiracetam is the first-line therapy due to its similar efficacy and more favourable side effect profile.
View Article and Find Full Text PDFPurpose: The purpose of this study was to evaluate the time to medication administration, clinical effect, and safety of a recent Pharmacy and Therapeutics Committee-approved change in the administration of levetiracetam from intravenous piggyback (IVPB) over 15 min to undiluted intravenous push (IVP) over 2-5 min at a large academic medical center.
Methods: The primary outcome was the time from order verification to the administration of IVP levetiracetam versus IVPB levetiracetam. The secondary outcome was any benzodiazepine administered in the time between levetiracetam order verification and administration in both groups.
Background:: Renal replacement therapy may enhance the elimination of barbiturates. Pentobarbital clearance during continuous venovenous hemofiltration (CVVH) has not been described previously. We report a patient case involving the measurement of serial pentobarbital levels during CVVH and review relevant literature characterizing extracorporeal pentobarbital elimination.
View Article and Find Full Text PDFPurpose: To summarize select critical care pharmacotherapy guidelines and studies published in 2016.
Summary: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 31 journals monthly for relevant pharmacotherapy articles and selected 107 articles for review over the course of 2016. Of those included in the monthly CCPLU, three guidelines and seven primary literature studies are reviewed here.
Objective: To report a case of Klebsiella pneumoniae carbapenemase (KPC)-producing K pneumoniae ventriculitis successfully treated with dual intraventricular plus systemic antibiotic therapy.
Case Summary: A 43-year-old woman with a ventriculoperitoneal shunt was transferred from a nursing home with fever, altered mental status, and leukocytosis. She was found to have KPC-producing K pneumoniae ventriculitis.