Publications by authors named "Karyn L Hentz"
Article Synopsis
- Bergman et al. (2015) disagree with our critique (Lamb et al., 2014) of the WHO-UNEP report on endocrine disrupting chemicals (EDCs) published in 2012.
- We highlight key differences in our perspectives, particularly around study selection and data presentation related to EDCs.
- Our response focuses on three main issues: the distinction between hazard and risk, differing methods for identifying hazards, and the absence of justification for treating EDCs differently from other chemical agents.
Early in 2013, the World Health Organization (WHO) released a 2012 update to the 2002 State of the Science of Endocrine Disrupting Chemicals. Several significant concerns have been identified that raise questions about conclusions reached in this report regarding endocrine disruption. First, the report is not a state-of-the-science review and does not follow the 2002 WHO recommended weight-of-evidence approach.
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- * Human studies often lack relevant data, making it difficult to assess the risks of TCE exposure, while animal studies (mainly in rats and mice) show systemic toxicity but mixed results for male reproductive effects.
- * Mouse studies indicate that TCE may harm sperm development and motility due to oxidative metabolites, suggesting that addressing systemic toxicity could also mitigate potential reproductive harm.