Bioassay-Guided Isolation of Guggulsterol I and Evaluation of Its Antioxidant Properties in Ethanol Extracts From Commiphora caudata Leaves.

The secondary metabolites of various parts of have shown a range of biological activities under both in vivo and in vitro conditions, particularly anti-inflammatory and antioxidant properties. While E-guggulsterone from this plant has been proven to have anti-inflammatory effects, the antioxidant potential of phytochemicals present in the leaves of is less explored. This investigation aimed to isolate an antioxidant phytoconstituent from the ethanolic extract of the dried leaves of using a bioassay-guided approach.

Challenges and mitigation strategies associated with Burkholderia cepacia complex contamination in pharmaceutical manufacturing.

Burkholderia cepacia complex (BCC) is a Gram-negative, non-spore-forming bacterium with more than 20 opportunistic pathogenic species, most commonly found in soil and water. Due to their rapid mutation rates, these organisms are adaptable and possess high genomic plasticity. BCC can cause life-threatening infections in immunocompromised individuals, such as those with cystic fibrosis, chronic granulomatous disease, and neonates.