Publications by authors named "Karunakar Rao Kudle"
Article Synopsis
- A new series of -butyl 2-(substituted benzamido) phenylcarbamates was synthesized using -butyl 2-amino phenylcarbamate and various substituted carboxylic acids, resulting in high yields.
- The synthesized compounds were tested for anti-inflammatory activity in rats, showing effectiveness comparable to the standard drug indomethacin, with inhibition rates between 39.021% and 54.239%.
- In silico docking studies were conducted to support the experimental findings and provide further insights into the compounds' potential as anti-inflammatory agents.
Cisplatin cytotoxicity is dependent on mitochondrial respiration in .
Iran J Basic Med Sci
January 2017
Objectives: To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells.
Materials And Methods: Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes in cytosol/mitochondrial compartments, reactive oxygen species production and respiratory control ratio.
Results: Wild-type yeast grown on glycerol exhibited heightened sensitivity to cisplatin than yeast grown on glucose.