Rifampicin Resistant Tuberculosis Among Presumptive Pulmonary Tuberculosis in Province Referral Hospital, Indonesia: Dynamic Cases of a 7-Year Report.

Background: Indonesia has the second highest tuberculosis (TB) cases globally. This study aimed to determine the sociodemographic factors associated with TB and rifampicin-resistant tuberculosis (RR-TB) cases among presumptive pulmonary TB patients in Aceh Referral Hospital. A retrospective cross-sectional study.

Tryptophan and Its Derived Metabolites as Biomarkers for Tuberculosis Disease: A Systematic Review.

Feasible diagnostic assays are required to detect new tuberculosis (TB) cases and monitor treatment. This study aimed to evaluate evidence on tryptophan (Trp) and its metabolites as proposed biomarkers for TB. Through specific keyword searches, we identified 170 relevant literature sources and included seven publications (from 2013 to 2023).

Knowledge and acceptance associated with medication adherence among hypertension individuals in Aceh province, Indonesia.

Low adherence to anti-hypertensive medication is observed among individuals in Aceh, the westernmost province of Indonesia. Since uncontrolled hypertension has the potential to develop into a life-threatening disease, exploring medication adherence among this specific population is essential. Therefore, this study aimed to evaluate knowledge and acceptance associated with medication adherence among hypertensive individuals in Aceh Province.

The Effects of Extract on Colonization and IL-31 Levels in Children with Atopic Dermatitis.

: The ineffective combination of corticosteroids and antibiotics in treating some atopic dermatitis (AD) cases has been concerning. The skin barrier defects in AD ease the colonization of (), which results in a rise in interleukin-31 (IL-31). () has shown antimicrobial and antiallergic effects but has not been studied yet to decrease the growth of and IL-31 levels in AD patients.

Antioxidant and phytometabolite profiles of ethanolic extract from the cascara pulp of collected from Gayo Highland: A study for potential anti-photoaging agent.

: As the most abundant coffee by-product, cascara pulp has been considered a good source of antioxidants which could be used to prevent photoaging. The aim of this study was to determine the phytometabolite profiles, antioxidant and photoaging properties of the ethanolic extract of cascara pulp. : Ethanolic maceration was performed on the fine powder of cascara pulp collected from Gayo Highland, Aceh Province, Indonesia.

Antioxidant and antiproliferative activities of n-hexane extract and its fractions from L. leaves.

is a plant species that has been popularly used to treat a broad spectrum of diseases. In efforts of tackling the increasing threat of cancers, has been studied for its anticancer potentials. Hence, through this research, we aimed to evaluate the antioxidant and antiproliferative activities of n-hexane extract from L.

Coffee by-products as the source of antioxidants: a systematic review.

Solid waste from coffee depulping process threatens the organism in environment as it produces organic pollutants. Evidence suggested that coffee by-product could valorize owing to its potential as antioxidant sources. The aim of this systematic review was to evaluate antioxidant activity of coffee by-products obtained from different coffee variants (arabica and robusta) and processing methods.

Antidepressant-like Activity of Patchouli Oil var. Tapak Tuan ( Benth) via Elevated Dopamine Level: A Study Using Rat Model.

Essential oils are gaining popularity for their use in treating depression, including that extracted from patchouli leaves and stems (Pogostemon cablin). Herein, we used patchouli oil (PO) containing a high amount of patchouli alcohol derived from P. cablin var.

Molecular docking investigation of calotropone as a potential natural therapeutic agent against pancreatic cancer.

A natural bioactive compound named calotropone has been reported as a drug candidate for several cancers, including pancreatic cancers. Herein, we used molecular docking approach to test the possible mechanisms of action of calotropone in inhibiting the growth of pancreatic cell cancer with gemcitabine as the positive control. By employing AutoDock Vina, we studied the molecular interaction between calotropone and pancreatic cancer-associated proteins, namely Glucosaminyl (N-Acetyl) Transferase 3, Glutamic-Oxaloacetic Transaminase 1, Tyrosine-protein kinase Met (c-Met), peroxisome proliferator-activated receptor γ, Budding Uninhibited by Benzimidazole 1, A Disintegrin and Metalloproteinase 10, Sex-determining region Y and Nuclear Factor kappa Beta (Nf-Kβ).

Molecular docking of two cytotoxic compounds from leaves against therapeutic molecular target of pancreatic cancer.

The utilization of natural compounds as therapeutic agents to treat pancreatic cancer has recently focused on natural drug research. has long been believed to be a medicinal plant that helps in treating various diseases. The bioactive compounds 9-metoxipinoresinol and isoliquiritigenin isolated from leaves are proven to act as therapeutic agents by inhibiting the cancer cell growth of Panc-1 cells.