Radioembolization plus Immune Checkpoint Inhibitor Therapy Compared with Radioembolization plus Tyrosine Kinase Inhibitor Therapy for the Treatment of Hepatocellular Carcinoma.

Purpose: To investigate if combination therapy with immune checkpoint inhibitor (ICI) and yttrium-90 (Y) radioembolization results in superior outcomes than those yielded by tyrosine kinase inhibitor (TKI) therapy and Y for the treatment of intermediate- to advanced-stage hepatocellular carcinoma (HCC).

Methods: A retrospective review of patients presented at an institutional multidisciplinary liver tumor board between January 1, 2012 and August 1, 2023 was conducted. In total, 44 patients with HCC who underwent Y 4 weeks within initiation of ICI or TKI therapy were included.

Deep learning on electronic medical records identifies distinct subphenotypes of diabetic kidney disease driven by genetic variations in the pathway.

Kidney disease affects 50% of all diabetic patients; however, prediction of disease progression has been challenging due to inherent disease heterogeneity. We use deep learning to identify novel genetic signatures prognostically associated with outcomes. Using autoencoders and unsupervised clustering of electronic health record data on 1,372 diabetic kidney disease patients, we establish two clusters with differential prevalence of end-stage kidney disease.

Automated electrocardiogram signal quality assessment based on Fourier analysis and template matching.

We developed and tested a novel template matching approach for signal quality assessment on electrocardiogram (ECG) data. A computational method was developed that uses a sinusoidal approximation to the QRS complex to generate a correlation value at every point of an ECG. The strength of this correlation can be numerically adapted into a 'score' for each segment of an ECG, which can be used to stratify signal quality.

CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.

Unlabelled: Proteins containing polyglutamine (polyQ) regions are found in almost all eukaryotes, albeit with various frequencies. In humans, proteins such as huntingtin (Htt) with abnormally expanded polyQ regions cause neurodegenerative diseases such as Huntington's disease (HD). To study how the presence of endogenous polyQ aggregation modulates polyQ aggregation and toxicity, we expressed polyQ expanded Htt fragments (polyQ Htt) in Schizosaccharomyces pombe In stark contrast to other unicellular fungi, such as Saccharomyces cerevisiae, S.