Histopathological Evaluation of Wound Healing and Anti-Inflammatory Effects of Granola Potato Peel Ethanol Extract in Rat Oral Mucosa.

Introduction: Oral mucosal wounds present significant clinical challenges due to their susceptibility to infection, inflammation, and delayed healing. The limitation of standard anti-inflammatory drugs (both steroidal and non-steroidal) highlights the urgent need for plant-derived alternative therapies. Granola potato ( L.

Perdanakusuma Score in Pressure Injury Compared with Falanga Score: A New Qualitative Wound Assessment Tool.

Background: Effective wound assessment is crucial for managing pressure injuries, necessitating a valid and reliable wound bed scoring system that is practical for clinicians. The Falanga score was replaced with the Perdanakusuma score at the Dr. Soetomo General Hospital.

Three new dihydrochalcones from the leaves of Jarrett and their activity against .

Three new dihydrochalcones: artoserichalcone A-C (), were isolated from the leaves of . The structures of compounds were determined based on NMR spectrum (H, C, and 2D) and HRESIMS spectroscopic analysis. Compounds () and () showed active antimalarial activity with IC values of 16.

The Effects of Potato ( L. vs. Granola; Solanaceae) Peel Extract Gel on Gingival Wound Healing in Wistar Rats.

Purpose: Phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties have been identified in potatoes ( L.; Solanaceae), which may potentially contribute to wound healing. The study aimed to evaluate the effect of potato peel extract gel Granola variety on oral gingival wound healing in Wistar Rats.

Development and validation of cost-effective SYBR Green-based RT-qPCR and its evaluation in a sample pooling strategy for detecting SARS-CoV-2 infection in the Indonesian setting.

A low-cost SYBR Green-based RT-qPCR method to detect SARS-CoV-2 were developed and validated. Primers targeting a conserved and vital region of the N genes of SARS-CoV-2 were designed. In-silico study was performed to analyse the compatibility of the selected primer pair with Indonesian SARS-CoV-2 genome sequences available from the GISAID database.

Alters One-Dimensional Profile of Serum Proteins Due to Mercury Chloride in Rats ().

<b>Background and Objective:</b> Several previous studies have shown that leaf ethanolic extract of <i>Etlingera hemisphaerica</i> (LE3H) has the potential to reduce the toxicity and teratogenicity effects of mercury. This study aimed to describe the effects of LE3H on the protein profile of <i>Rattus norvegicus</i> serum due to treatment with HgCl₂. <b>Materials and Methods:</b> Four groups of male rats, K1 was injected intraperitoneally (IP) HgCl₂ (5 mg kg¹ b.

Chewing and Swallowing Patterns for Different Food Textures in Healthy Subjects.

Aims: This study aimed to determine the patterns of chewing and swallowing in healthy subjects with different food textures.

Methods: This cross-sectional study included 75 subjects who were asked to video record themselves while chewing different food samples of varying textures, including sweet and salty food. The food samples were coco jelly, gummy jelly, biscuit, potato crisp, and roasted nuts.

Oral Health-Related Quality of Life (OHRQoL) Analysis in Partially Edentulous Patients with and without Denture Therapy.

Purpose: One of the Indonesians oral health problems today is teeth loss. Several treatments can be done to overcome the problems, especially to restore missing teeth function, which are mastication, speech function, and improve aesthetic. The aim of this study was to analyze the correlation between oral health-related quality of life (OHRQoL) domains physical health, psychological health, social relationships, environment, and the domain of Oral Impact on Daily Performance (OIDP) in partially edentulous patients with implants, conventional dentures, and non-users (without implant and conventional denture).

Use of a Three-dimensional Smartphone Scanner in the Quantitative Analysis of Repaired Unilateral Cleft Lip during the Coronavirus Disease Pandemic.

Unlabelled: Cleft lip, a major craniofacial abnormality, is highly prevalent among people with low socioeconomic status in Indonesia. Direct two-dimensional measurement of the affected region is the gold standard for surgical preparation; however, its compliance and usability are limited in pediatric patients. Modern smartphones, including iPhones, are equipped with high-resolution cameras, which can record images and videos of a face.

Nata de Cassava Type of Bacterial Cellulose Doped with Phosphoric Acid as a Proton Exchange Membrane.

This work aims to encourage the use of natural materials for advanced energy applications, such as proton exchange membranes in fuel cells. Herein, a new conductive membrane produced from cassava liquid waste was used to overcome environmental pollution and the global crisis of energy. The membrane was phosphorylated through a microwave-assisted method with different phosphoric acid, (HPO) concentrations (10-60 mmol).

Endophytic microbiome of Boehmeria nivea and their antagonism against latent fungal pathogens in plants.

Pathogenic microbes still become obstacles that can reduce the quality of plant growth, including ramie (Boehmeria nivea) plants. The study identified the microbiome and antagonistic interaction of the endophytic community from the B. nivea is necessary to improve the production of the ramie plant, especially ramie stem organs for fiber materials.

The Role of Simple Blood Tests and a Modified Chest X-Ray Scoring System in Assessing the Severity Disease and Mortality Risk in COVID-19 Patients in a Secondary Hospital, Indonesia.

Background: Coronavirus disease 2019 (COVID-19) has resulted in millions of mortality cases and significant incremental costs to the healthcare system. Examination of CRP and D-dimer were considered to have higher costs, and the use of simple hematological parameters such as lymphocyte, neutrophil, and white blood cell (WBC) which have more affordable costs would be cost-saving. Radiological imaging complements clinical evaluation and laboratory parameters for managing COVID-19 patients.

Spontaneous expression of the gene of and in cynomolgus monkeys infected with papillomavirus.

Background And Aim: Cynomolgus monkeys () develop spontaneous infection of Papillomavirus (PV); thus, potentially beneficial for modeling human PV (HPV) infection study. Contrary to human origin, infection in cynomolgus monkeys does not always show evident clinical symptoms of cervical cancer. The absence of cervical cancer clinical symptoms leads us to investigate the molecular mechanism of the HPV infection in cynomolgus monkeys.

Comparative cytokine profiling identifies common and unique serum cytokine responses in acute chikungunya and dengue virus infection.

Background: Infection by chikungunya (CHIKV) and dengue virus (DENV) can cause a wide spectrum of clinical features, many of which are undifferentiated. Cytokines, which broadly also include chemokines and growth factors, have been shown to play a role in protective immunity as well as DENV and CHIKV pathogenesis. However, differences in cytokine response to both viruses remain poorly understood, especially in patients from countries where both viruses are endemic.

Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B.

Background: Chronic hepatitis B is a necro-inflammatory of the liver parenchyma caused by hepatitis B virus (HBV) infection leading to liver cirrhosis and hepatocellular carcinoma (HCC). Genetic variants including single nucleotide polymorphisms (SNPs) within genes regulating immune response may contribute to the progression of chronic hepatitis B (CHB) infection. This study aimed to examine the genotype distribution of vitamin D receptor (VDR) polymorphism among patients with CHB infection and to study its association with the development of cirrhosis and hepatoma.

Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis.

The phytohormone cytokinin plays a significant role in nearly all aspects of plant growth and development. Cytokinin signaling has primarily been studied in the dicot model Arabidopsis, with relatively little work done in monocots, which include rice (Oryza sativa) and other cereals of agronomic importance. The cytokinin signaling pathway is a phosphorelay comprised of the histidine kinase receptors, the authentic histidine phosphotransfer proteins (AHPs) and type-B response regulators (RRs).

Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.

Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-encephalitic acute febrile illness patients from Bali, Indonesia. Paired admission (S1) and discharge (S2) serum specimens from 144 acute febrile illness patients (without evidence of acute dengue virus infection) were retrospectively tested for anti-JEV IgM antibody and confirmed by plaque reduction neutralization test (PRNT) for JEV infection.

Chikungunya fever outbreak identified in North Bali, Indonesia.

Background: Chikungunya virus (CHIKV) infections have been reported sporadically within the last 5 years in several areas of Indonesia including Bali. Most of the reports, however, have lacked laboratory confirmation.

Method: A recent fever outbreak in a village in the North Bali area was investigated using extensive viral diagnostic testing including both molecular and serological approaches.

A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia.

Genome-wide association studies (GWASs) of the entire genome provide a systematic approach for revealing novel genetic susceptibility loci for breast cancer. However, genetic association studies have hitherto been primarily conducted in women of European ancestry. Therefofre we here performed a pilot GWAS with a single nucleotide polymorphism (SNP) array 5.