Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density.

Surgical intervention for the treatment of intracerebral hemorrhage (ICH) has been limited by inadequate lysis of the target thrombus. Adjuvant transcranial ultrasound exposure is hypothesized to improve thrombolysis, expedite hematoma evacuation and improve clinical outcomes. A juvenile porcine intracerebral hemorrhage model was established by direct infusion of autologous blood into the porcine white matter.

An automated detection of glaucoma using histogram features.

Glaucoma is a chronic and progressive optic neurodegenerative disease leading to vision deterioration and in most cases produce increased pressure within the eye. This is due to the backup of fluid in the eye; it causes damage to the optic nerve. Hence, early detection diagnosis and treatment of an eye help to prevent the loss of vision.

Synthesis of Some P-Trifluoromethyl-Substituted (Silylamino)phosphines, N-Silylphosphoranimines, and Phosphazenes.

Treatment of P-chloro-substituted (silylamino)phosphines, (Me(3)Si)(2)NP(R)Cl, with the trifluoromethylating agent, [(Et(2)N)(3)PBr(+)](CF(3)(-)) [generated in situ from CF(3)Br and (Et(2)N)(3)P], readily affords the corresponding P-trifluoromethylphosphines, (Me(3)Si)(2)NP(R)CF(3) (4, R = Ph; 5, R = n-Pr). Subsequent oxidative halogenation of 4 and 5 with X(2) (X = Cl, Br, I) occurs with loss of Me(3)SiX to yield the P-halo-P-trifluoromethyl-N-silylphosphoranimines, Me(3)SiN=P(R)(CF(3))X (6a-c; R = Ph; 7a-c, R = n-Pr). The P-Br compounds 6b and 7b were then converted to the P-trifluoroethoxy, Me(3)SiN=P(R)(CF(3))OCH(2)CF(3) (8, R = Ph; 9, R = n-Pr), and P-phenoxy, Me(3)SiN=P(R)(CF(3))OPh (10, R = Ph; 11, R = n-Pr), derivatives by nucleophilic substitution reactions with LiOCH(2)CF(3) and LiOPh, respectively.