Identification of the targeted therapeutic potential of doxycycline for a subset of gastric cancer patients.

The identification of new drugs for the targeted therapy of gastric cancer remains an important need. The RAS/RAF/MEK/ERK/ELK1 signaling cascade is activated in many cancers, including gastric cancer. To identify the targetable inhibitors of the ERK/MAPK pathway, we performed a repurposing screening of a panel of antimicrobial agents in gastric cancer cells using an ERK/MAPK-driven firefly luciferase reporter assay.

Genome of a known but distinct begomovirus associated with a novel satellite molecule infecting a new host bitter gourd ().

(KY860899), (KY860898) and (KY848691) were found to be associated with leaf curl disease in (bitter gourd). The complete nucleotide sequence of showed 82% identity with (KM244719), whereas was 96% identical to (KP868764) and illustrated 81% similarity with (JQ041697). Phylogenetic and RDP analysis revealed the proximity of these begomoviruses with other monopartite begomoviruses and alphasatellites already reported from India.