Serum megalin levels in type-2 diabetes mellitus with and without cardiovascular disease.

Background: Low-density lipoprotein receptor-related protein-2 (LRP2), also called megalin, is a multi-ligand receptor of the LDL receptor gene family mediating reabsorption of ligands like Apo-A1. Type 2 diabetes mellitus (T2DM) may possibly disrupt megalin functions as it is found to be regulated by insulin. This might cause cardiovascular complications due to derangement in lipoprotein metabolism.

Beyond digital interfaces: The human element in online teaching and its influence on student experiences.

Amidst the digital transformation of education, the essence of the human touch in online teaching remains pivotal. Despite growing literature, there remains a significant gap in understanding how the human element in online teaching directly influences student engagement and learning outcomes, especially in diverse educational contexts. This study develops a quantifiable index capturing the essence of humanized online teaching and investigates the determinants influencing this humanization.

Automated Prediction of Malignant Melanoma using Two-Stage Convolutional Neural Network.

Purpose: A skin lesion refers to an area of the skin that exhibits anomalous growth or distinctive visual characteristics compared to the surrounding skin. Benign skin lesions are noncancerous and generally pose no threat. These irregular skin growths can vary in appearance.

Single-Atomic Co-N Sites with CrCo Nanoparticles for Metal-Air Battery-Driven Hydrogen Evolution.

Designing highly active and robust earth abundant trifunctional electrocatalysts for energy storage and conversion applications remain an enormous challenge. Herein, we report a trifunctional electrocatalyst (CrCo/CoN@CNT-5), synthesized at low calcination temperature (550 °C), which consists of Co-N single atom and CrCo alloy nanoparticles and exhibits outstanding electrocatalytic performance for the hydrogen evolution reaction, oxygen evolution reaction, and oxygen reduction reaction. The catalyst is able to deliver a current density of 10 mA cm in an alkaline electrolytic cell at a very low cell voltage of ∼1.

Coupling Single-Ni-Atom with Ni-Co Alloy Nanoparticle for Synergistically Enhanced Oxygen Reduction Reaction.

Developing nonprecious metal-based oxygen reduction reaction (ORR) electrocatalysts with superior activity and durability is crucial for commercializing proton-exchange membrane (PEM) fuel cells. Herein, we report a metal-organic framework (MOF)-derived unique N-doped hollow carbon structure (NiCo/hNC), comprising of atomically dispersed single-Ni-atom (NiN) and small NiCo alloy nanoparticles (NPs), for highly efficient and durable ORR catalysis in both alkaline and acidic electrolytes. Density functional theory (DFT) calculations reveal the strong coupling between NiN and NiCo NPs, favoring the direct 4e transfer ORR process by lengthening the adsorbed O-O bond.

An anonymization-based privacy-preserving data collection protocol for digital health data.

Digital health data collection is vital for healthcare and medical research. But it contains sensitive information about patients, which makes it challenging. To collect health data without privacy breaches, it must be secured between the data owner and the collector.

Health Informatics: Engaging Modern Healthcare Units: A Brief Overview.

In the current scenario, with a large amount of unstructured data, Health Informatics is gaining traction, allowing Healthcare Units to leverage and make meaningful insights for doctors and decision-makers with relevant information to scale operations and predict the future view of treatments Information Systems Communication. Now, around the world, massive amounts of data are being collected and analyzed for better patient diagnosis and treatment, improving public health systems and assisting government agencies in designing and implementing public health policies, instilling confidence in future generations who want to use better public health systems. This article provides an overview of the HL7 FHIR Architecture, including the workflow state, linkages, and various informatics approaches used in healthcare units.

Clinical spectrum and short-term outcomes of multisystem inflammatory syndrome in children in a south Indian hospital.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a new hyperinflammatory variant that evolved during the coronavirus disease 2019 pandemic. Although the precise pathophysiology of MIS-C is uncertain, it is thought to be due to immune dysregulation occurring after recovery from acute infection.

Purpose: Our study aimed to analyze the clinical spectrum, laboratory parameters, imaging characteristics, treatment strategies, and short-term outcomes of children with a diagnosis of MIS-C.

Synthesis and Properties of Monolayer MnSe with Unusual Atomic Structure and Antiferromagnetic Ordering.

Transition metal chalcogenides (TMCs) are a large family of 2D materials that are currently attracting intense interest. TMCs with 3d transition metals provide opportunities for introducing magnetism and strong correlations into the material with manganese standing out as a particularly attractive option due to its large magnetic moment. Here we report on the successful synthesis of monolayer manganese selenide on a NbSe substrate.

FractalCovNet architecture for COVID-19 Chest X-ray image Classification and CT-scan image Segmentation.

Precise and fast diagnosis of COVID-19 cases play a vital role in early stage of medical treatment and prevention. Automatic detection of COVID-19 cases using the chest X-ray images and chest CT-scan images will be helpful to reduce the impact of this pandemic on the human society. We have developed a novel FractalCovNet architecture using Fractal blocks and U-Net for segmentation of chest CT-scan images to localize the lesion region.

Effectiveness of team teaching in biochemistry lectures for undergraduate students.

Team teaching is an innovative method to engage the large group and make lectures more interesting. The aim of the study is to evaluate the impact of team teaching in first year biochemistry lecture classes. After obtaining ethical clearance, 150 first year medical undergraduate students participated in the study on a voluntary basis.

Evaluation of Clinical Efficacy of Advanced Platelet-Rich Fibrin in the Management of Gingival Recession Defects: Case Series.

Introduction: The purpose of this case series is to evaluate the clinical efficacy of advanced platelet-rich fibrin (A-PRF) in combination with coronally advanced flap (CAF) in the management of gingival recession defects and its first of its kind.

Case Series: Fourteen systemically healthy patients presenting with 35 RT1 recession defects were treated with A-PRF + CAF. Recession height (RH), recession width (RW), probing pocket depth (PPD), clinical attachment level (CAL), keratinized tissue height (KTH), and width of attached gingiva (WAG) were measured at baseline, 3, and 6 months.

Formation of Highly Doped Nanostripes in 2D Transition Metal Dichalcogenides via a Dislocation Climb Mechanism.

Doping of materials beyond the dopant solubility limit remains a challenge, especially when spatially nonuniform doping is required. In 2D materials with a high surface-to-volume ratio, such as transition metal dichalcogenides, various post-synthesis approaches to doping have been demonstrated, but full control over spatial distribution of dopants remains a challenge. A post-growth doping of single layers of WSe is performed by adding transition metal (TM) atoms in a two-step process, which includes annealing followed by deposition of dopants together with Se or S.

Efficient Exfoliation of Layered Double Hydroxides; Effect of Cationic Ratio, Hydration State, Anions and Their Orientations.

The exfoliation ability of nitrate based MgAl(OH)(NO)·HO layered double hydroxides (Mg-Al LDH) in formamide into single or multilayer nanosheets depends strongly on nitrate anion orientation and layer charge. Our systematic studies used materials that were likely to disclose differences with respect to anion type and their concentrations in the interlayer gallery. We assured to avoid any carbonate incorporation into the galleries for nitrate, chloride, iodide, and sulfate based Mg-Al LDHs.

Fluorine-enriched mesoporous carbon as efficient oxygen reduction catalyst: understanding the defects in porous matrix and fuel cell applications.

Herein, fluorine enrichment in mesoporous carbon (F-MC) was explored to introduce maximum charge polarization in the porous matrix, which is beneficial for the preferential orientation of O molecules and their subsequent reduction. doping of F to porous carbon derived from phloroglucinol-formaldehyde resin using Pluronic F-127 as a structure-directing agent is standardized. The optimized F-MC catalyst exhibited excellent electrocatalytic activity towards the oxygen reduction reaction (ORR) in alkaline media (0.

Computational Approach To Reveal the Structural Stability and Electronic Properties of Lithiated M/CNT (M = Si, Ge) Nanocomposites as Anodes for Lithium-Ion Batteries.

This work is motivated to explore the structural stability and electronic and electrochemical properties of nanocomposites of MLi (M = Si and Ge)-carbon nanotube (CNT) by employing first-principles density functional theory calculations. By analyzing the structural stability of various MLi ( = 0-10) clusters, it is revealed that a tetrahedron-shaped MLi Zintl cluster is found to be highly stable. Our study on the interaction between the lithiated clusters and CNT illustrates that the charge transfer from the former to latter plays a pivotal role in stabilizing these nanocomposites.

Which Transition Metal Atoms Can Be Embedded into Two-Dimensional Molybdenum Dichalcogenides and Add Magnetism?

As compared to bulk solids, large surface-to-volume ratio of two-dimensional (2D) materials may open new opportunities for postsynthesis introduction of impurities into these systems by, for example, vapor deposition. However, it does not work for graphene or h-BN, as the dopant atoms prefer clustering on the surface of the material instead of getting integrated into the atomic network. Using extensive first-principles calculations, we show that counterintuitively most transition metal (TM) atoms can be embedded into the atomic network of the pristine molybdenum dichalcogenides (MoDCs) upon atom deposition at moderate temperatures either as interstitials or substitutional impurities, especially in MoTe, which has the largest spacing between the host atoms.

Diode Laser as an Adjunct to Kirkland Flap Surgery-A Randomized Split-Mouth Clinical and Microbiological Study.

Mechanical methods of periodontal therapy alone may fail to eliminate the tissue-invasive pathogenic flora; therefore, considerable attention has been given to adjunctive antimicrobial measures. The aim of this study was to investigate and compare the clinical and microbiological effects of diode laser (DL) as an adjunct to Kirkland flap surgery versus Kirkland flap surgery alone for the treatment of generalized chronic periodontitis. A total of 20 patients with generalized chronic periodontitis with probing pocket depth ≥5 mm after phase I therapy were included in this split-mouth study.

d orbital-mediated bound magnetic polarons in ferromagnetic Ce-doped BaTiO nanoparticles and their enriched two-photon absorption cross-section.

The enriched ferromagnetism and two-photon absorption (TPA) cross-section of perovskite BaTiO3 nanoparticles are indispensable for magnetic and optical data storage applications. In this work, hydrothermally synthesized Ce-doped BaTiO3 nanoparticles exhibited the maximum room temperature ferromagnetism (4.26 × 10-3 emu g-1) at 4 mol% due to the increase in oxygen vacancies, as evidenced by X-ray photoelectron and electron spin resonance spectroscopy and density functional theory (DFT) calculations.

Diagnostic Usefulness of Serum Albumin as a Predictor of Diabetic Ketoacidosis.

Context: Diabetes mellitus is one of the most prevalent diseases worldwide. One of the acute complications of diabetes mellitus is diabetic ketoacidosis. It becomes essential for the healthcare physicians to identify the individuals who are likely to be prone to the development of ketosis.

Borophene layers on an Al(111) surface - the finding of a borophene layer with hexagonal double chains and B nonagons using ab initio calculations.

We studied the stability of several borophene layers on an Al(111) surface and found a structure called 9R using ab initio calculations. This layer competes with χ3 and β12 borophene layers and is made up of boron nonagons that form a network of hexagonal boron double chains. Remarkably, it has no B6 hexagon unlike other borophene layers.

Unveiling the multifunctional roles of hitherto known capping ligand oleic acid as blue emitter and sensitizer in tuning the emission colour to white in red-emitting phosphors.

Capping ligands are vital in stabilizing various nanostructures and semiconductor quantum dots in which unusual optical properties, especially white light emission, have been realized. Oleic acid (OA) is a widely used capping ligand. Here, we report blue emission from OA in its free molecular form and further demonstrate this by anchoring OA over the surfaces of Al2O3, ZnAl2O4(ZA), ZnAl2O4:Eu3+ (ZA:Eu3+), and Y2O3:Eu3+.

Cooked Food Waste-An Efficient and Less Expensive Precursor for the Generation of Activated Carbon.

Activated carbon was synthesized from cooked food waste, especially dehydrated rice kernels, by chemical activation method using NaOH and KOH as activating agents. It was then characterized by ultimate and proximate analysis, BET surface analysis, XRD, FTIR, Raman and SEM. The XRD patterns and Raman spectra confirmed the amorphous nature of the prepared activated carbons.

Tuning of intrinsic antiferromagnetic to ferromagnetic ordering in microporous α-MnO by inducing tensile strain.

By employing first principles density functional calculations, we investigated an α-MnO compound with a tunnel framework, which provides an eminent platform to alter the intrinsic antiferromagnetic (AFM) to ferromagnetic (FM) ordering, through the introduction of chemical or mechanical tensile strain. Our calculations further showed that the strength of FM ordering increases until 10% triaxial tensile strain. Since long range FM ordering is induced, it is realized to be superior as compared to the experimentally observed short-range FM ordering in oxygen-deficient compound.

First principles modeling of Mo6S9 nanowires via condensation of Mo4S6 clusters and the effect of iodine doping on structural and electronic properties.

By employing first principles DFT calculations, we propose a new stable model for Mo6S9 nanowires (NWs) obtained by condensing tetrahedral Mo4S6 clusters rather than octahedral Mo6S8 clusters, which are known as magic clusters in the Mo-S polyhedral cluster family. The pristine NW is found to be metallic and its local structure and physical properties can be tuned by doping of iodine atoms. This doping increases the number of Mo-Mo bonds in the NW, thus, Mo4 tetrahedra are initially fused to the Mo6 octahedron, and then, to the Mo8 dodecahedron.