Is Laccase derived from Pleurotus ostreatus effective in microplastic degradation? A critical review of current progress, challenges, and future prospects.

Exploration of Pleurotus ostreatus as a biological agent in the degradation of persistent plastics like polyethylene, polystyrene, polyvinyl chloride, and polyethylene terephthalate, revealing a promising avenue toward mitigating the environmental impacts of plastic pollution. Leveraging the intrinsic enzymatic capabilities of this fungus, mainly its production of laccase, presents a sustainable and eco-friendly approach to breaking down complex polymer chains into less harmful constituents. This review focused on enhancements in the strain's efficiency through genetic engineering, optimized culture conditions, and enzyme immobilization to underscore the potential for scalability and practical application of this bioremediation process.

Targeting cyclin-dependent kinase 2 CDK2: Insights from molecular docking and dynamics simulation - A systematic computational approach to discover novel cancer therapeutics.

Global public health is confronted with significant challenges due to the prevalence of cancer and the emergence of treatment resistance. This work focuses on the identification of cyclin-dependent kinase 2 (CDK2) through a systematic computational approach to discover novel cancer therapeutics. A ligand-based pharmacophore model was initially developed using a training set of seven potent CDK2 inhibitors.

A review on vulnerable atmospheric aerosol nanoparticles: Sources, impact on the health, ecosystem and management strategies.

The Earth's atmosphere contains ultrafine particles known as aerosols, which can be either liquid or solid particles suspended in gas. These aerosols originate from both natural sources and human activities, termed primary and secondary sources respectively. They have significant impacts on the environment, particularly when they transform into ultrafine particles or aerosol nanoparticles, due to their extremely fine atomic structure.

Identification of novel CA IX inhibitor: Pharmacophore modeling, docking, DFT, and dynamic simulation.

Human Carbonic anhydrase IX (hCA IX) is found to be an essential biomarker for the treatment of hypoxic tumors in both the early and metastatic stages of cancer. Due to its active function in maintaining pH levels and overexpression in hypoxic conditions, hCA IX inhibitors can be a potential candidate specifically designed to target cancer development at various stages. In search of selective hCA IX inhibitors, we developed a pharmacophore model from the existing natural product inhibitors with IC values less than 50 nm.

Biocompatible nanoscale silica particles fabricated from aminopropyltriethoxysilane functionalized brick ash induced versatile pesticidal activity.

The present study is aimed to evaluate pesticidal activity and biocompatibility including ecotoxicity of functionalized silica nanoparticles that synthesized by simple, in vitro, green technology principles. Sol-gel method was adopted for the synthesis of silica nanoparticles and was functionalized by Aminopropyltriethoxysilane (APS), characterized and confirmed the uniform, monodispersive, highly stable particles with the size range of 10-200 nm. The synthesized Nano silica was screened against the developmental stages of Spodoptera litura.

Noteworthy biocompatibility of effective microorganisms (EM) like microbial beneficial culture formulation with metal and metal oxide nanoparticles.

The present study evaluates the biocompatibility of silver and zinc oxide nanoparticles with various effective microorganisms (EM), like beneficial microbial formulations. The respective nanoparticle was synthesised by chemical reduction of metal precursor with reducer via simple route green technology principles. The synthesised nanoparticles were characterised by UV visible spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD) studies, revealing highly stable, nanoscale particles with marked crystallinity.

Evaluation of methyl orange adsorption potential of green synthesized chitosan-silver nanocomposite (CS-AgNC) and its notable biocompatibility on freshwater Tilapia (Oreochromis nitoticus).

Nanomaterials mainly nanocomposites possess unique physical and chemical properties which makes them superior and indispensable. Though much research has been focused on the properties and application of nanocomposites, the eco-toxicity assessment is one among top priority, which aims to protect the population of concerned biological component and their ecosystem. With this objective, the present study has undertaken an initiation to evaluate the efficacy of chitosan-silver nanocomposite for methyl orange adsorption property (CS-AgNC) and also assessed the toxicity impact on growth parameters of freshwater Tilapia.

Green chemistry principles for the synthesis of anti fungal active gum acacia-gold nanocomposite - natamycin (GA-AuNC-NT) against food spoilage fungal strain Aspergillus ochraceopealiformis and its marked Congo red dye adsorption efficacy.

In this present study, a highly stable gum acacia -gold nanocomposite fabricated with food preservative agent natamycin (GA-AuNC-NT) was prepared via green science principles under in vitro conditions. Various characterisation techniques reveal highly stable structural, functional properties of the synthesised nanocomposite with marked antifungal activity and adsorption efficacy against congo red dye. The antifungal activity was investigated against the fungal strain Aspergillus ochraceopealiformis isolated from spoiled, expired bread.

Surface-modified nanosilica-chitinase (SiNp-Chs)-doped nano enzyme conjugate and its synergistic pesticidal activity with plant extracts against armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae).

A laboratory experiment was conducted to evaluate enhanced pesticidal activity of silica nanoparticles-doped chitinase nano enzyme conjugate against an economically important insect pest Spodoptera litura (Fab.) (Lepidoptera; Noctuidae). Silica nanoparticles were synthesized by hydrolysis and condensation of precursor tetraethylorthosilicate (TEOS) followed by functionalization with functioning agent 3-aminopropyltriethoxysilane.

Terminalia chebula and Ficus racemosa principles mediated repression of novel drug target Las R - the transcriptional regulator and its controlled virulence factors produced by multiple drug resistant Pseudomonas aeruginosa - Biocompatible formulation against drug resistant bacteria.

Pseudomonas aeruginosa- major group of an aerobic bacteria associated with nosocomial and other life threatening infections. Diverse virulence factors produced by P. aeruginosa is due to distinct molecular cell signaling mechanism termed as quorum sensing (QS).

Insecticidal fungal metabolites fabricated chitosan nanocomposite (IM-CNC) preparation for the enhanced larvicidal activity - An effective strategy for green pesticide against economic important insect pests.

In the present study, enhanced pesticidal activity and biocompatibility of chitosan nanocomposite prepared with biocompatible polymer chitosan - insecticidal metabolites derived from potential fungal biopesticidal agent Nomuraea rileyi were studied. Insecticidal metabolites were isolated from the culture filtrate of fungal strain grown in sabouraud maltose yeast extract broth (SMYB) and the collected filtrate was extracted with ethyl acetate followed by purification using G-60 silica gel column. Chitosan nanocomposite was prepared with metabolites thus acquired by ionic gelation method.