[On theory of sensory conflict under exposure to physical factors: main principles and concepts of formation].

The article presents results of longstanding studies on influence of occupational physical factors on workers health. Experimental and nature studies helped to justify basic concepts of sensory conflict theory, a trigger of occupational disease formation. Patients having occupational disease present disorders of cortex-subcortex relationships on diencephal level, central and peripheral regulatory mechanisms, central sensory mechanisms participation in pathologic processes development, changes in vegetative regulation on cerebral level, demyelination and axon demyelination changes in peripheral nerves of upper and lower limbs.

[Dynamics of morphofunctional state of central nervous system in white rates exposed to vibration].

The authors presented results of experimental studies assessing influence of vibration on white rats. Dynamics of morphologic changes development in brain of experimental animals exposed to vibration were shown. Exposure to vibration in white rats daily during 4 hours over 15 days causes astrogliosis--compensation process in response to brain injury; over 1 month--causes morphologic brain changes (vacuoles formation in neuropile, decrease in astroglia cells number); over 2 months--causes lower plasticity of brain neurons, preserved astrogliosis; over 4 months--causes perivascular edema.

[Bioelectric brain activity under exposure to vibration].

Patients with vibration disease caused by local vibration and those with the disease caused by general vibration demonstrate similar changes in regulation of central nervous system, as shown by EEG--diffuse changes and locus of pathologic activity mostly in right temporal cortex. Unlike local vibration, the combined one acting long (over 10-15 years) causes more pathologic changes in brain, not only in cerebral cortex, but also in brainstem and diencephalic structures.

[Topographic mapping in comparative evaluation of brain electric activity in individuals with occupational vs. somatic diseases].

The authors presented results of topographic mapping and comparative evaluation of EEC patterns in patients with occupational and non-occupational diseases, apparently healthy individuals. Findings are unidirectional changes in EEC parameters among occupational diseases patients.

[Clinical cases of occupational chronic manganese intoxication].

Classic symptoms of manganese intoxication are very rarely seen nowadays. Clinic in Angarsk Research Institute for Occupational medicine and Human ecology registered two cases of stage I and II chronic manganese intoxication over 10 years among electric welders. The cases were diagnosed with consideration of long length of exposure to manganese with the ambient air level exceeding the MAC 1.

[Characteristics of long latent auditory evoked potentials under workers' exposure to occupational local vibration and noise].

Diagnosed changes in long latent auditory evoked potentials confirm central nervous system disorders in patients long exposed to vibration and noise. These changes are lower rate of activation spread in afferent pathways and delayed response on cortical and subcortical levels. Local vibration and noise in humans cause formation of unidirectional mechanisms of pathologic response.

[Defining functional state of peripheral nervous system in patients with vibration disease and occupational sensorineural deafness according to electroneuromyography parameters].

Pathological changes of the state of peripheral nerves according to data of electroneuromyography examination were observed both in patients with vibration disease as a result of local vibration impact and in patients with occupational sensorineural deafness. This suggests general mechanism of impact of physical factors on the human organism. In the first case observed changes were of more expressed character.

[Features of nervous system involvement under stress influence by occupational physical factors].

Somatosensory and auditory evoked potentials prove central and peripheral nervous system disorders in patients long exposed to vibration. Those disorders are altered impulse conductivity at all levels including peripheral neuron to nerve trunk, from the trunk to primary somatosensory cortex. Vibration is potent chronic stressor causing complicated neuroreflectory and neurohumoral disorders.