The Homolog of the Gene of the BTP1 Phage from Salmonella enterica Serovar Typhimurium ST313 Is an Antivirulence Gene in Salmonella enterica Serovar Dublin.

In a previous study, a novel virulence gene, , identified in a serovar Typhimurium sequence type 313 (ST313) strain was found to be conserved in all published serovar Dublin genomes. In order to analyze the role of this gene in the host-pathogen interaction in Dublin, a mutant where this gene was deleted ( Dublin Δ) and a mutant which was further genetically complemented with ( Dublin 3246-C) were constructed and tested in models of and infection as well as during growth competition assays in M9 medium, Luria-Bertani broth, and cattle blood. In contrast to the results obtained for a strain of Typhimurium ST313, the lack of was found to be associated with increased virulence in Dublin.