Publications by authors named "Karsten Vestergard"
Cholinergic changes play a fundamental role in the natural history of dementia with Lewy bodies and Lewy body disease in general. Despite important achievements in the field of cholinergic research, significant challenges remain. We conducted a study with four main objectives: (i) to examine the integrity of cholinergic terminals in newly diagnosed dementia with Lewy bodies; (ii) to disentangle the cholinergic contribution to dementia by comparing cholinergic changes in Lewy body patients with and without dementia; (iii) to investigate the in vivo relationship between cholinergic terminal loss and atrophy of cholinergic cell clusters in the basal forebrain at different stages of Lewy body disease; and (iv) to test whether any asymmetrical degeneration in cholinergic terminals would correlate with motor dysfunction and hypometabolism.
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- Alzheimer's Disease (AD) is a complicated illness, and scientists are exploring new ways to understand what causes it by looking at specific substances (metabolites) in our bodies.
- In a study, researchers tested blood samples from people with AD, those with Mild Cognitive Impairment (MCI), and healthy individuals to find important differences in these substances.
- They found six specific metabolites in blood that could help identify AD, but no significant differences were seen in extracellular vesicles (EVs), suggesting that more research is needed to use EVs effectively in studying this disease.
Article Synopsis
- Alzheimer's disease (AD) is the most common type of dementia and researchers are trying to find ways to identify it through blood tests.
- They studied tiny particles in the blood called extracellular vesicles (EVs) from patients with AD, mild cognitive impairment (MCI), and healthy people to see if they could discover any useful biomarkers.
- Some specific proteins were found to be much higher in AD patients, suggesting that these proteins could help in diagnosing AD, especially since some MCI patients ended up developing AD later on.
Article Synopsis
- Scientists are trying to find out more about Alzheimer’s disease by looking at proteins in blood and tiny particles called extracellular vesicles (EVs).
- They studied a total of 30 people: 10 with Alzheimer’s, 10 with mild memory issues (MCI), and 10 healthy people.
- They discovered some proteins in EVs that could help tell the difference between healthy people and those affected by Alzheimer’s, which might help in earlier diagnosis.
A 16-year-old girl was diagnosed with widely distributed dural sinus thrombosis (DST) and a haemorrhagic infarct in the left parietal lobe. Despite of heparin treatment, pronounced aggravation of symptoms was observed. Through a femoral vein approach a micro-catheter was advanced into the superior sagittal sinus and rt-PA was infused slowly, directly into the thrombus over 24 hours.
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