Publications by authors named "Karsten Petersen"
Is paternal age associated with transfer day, developmental stage, morphology, and initial hCG-rise of the competent blastocyst leading to live birth? A multicenter cohort study.
PLoS One
August 2022
Article Synopsis
- - This study explored how the age of men undergoing assisted reproductive technology (ART) affects factors like the day of blastocyst transfer, its stage, morphology, and the initial hCG rise related to achieving a live birth.
- - Analyzing data from 4842 couples, the results indicated that as men's age increases, there’s a 6% higher chance that the competent blastocyst is transferred on day 6 instead of day 5, particularly in controlled ovarian stimulation (COS) treatments.
- - The study suggests that older paternal age is linked to lower initial hCG levels, likely due to the increased time needed for oocytes to repair sperm DNA fragmentation, highlighting a potential area for future research in male reproductive
Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study.
Fertil Steril
March 2021
Objective: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.
Design: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.
Setting: Sixteen private and university-based facilities.
The maintenance of pluripotency of human embryonic stem cells (hESCs) requires a high efficiency of self-renewal. During in vitro propagation, however, spontaneous differentiation occurs frequently, and there is also a risk of chromosomal changes. In this study, we assessed the properties of hESCs after long-term culture at ambient air and 5% oxygen growth conditions.
View Article and Find Full Text PDFEgg-donation is an efficient treatment of female infertility caused by ovarian failure. Although the use of volunteer donors has been allowed in Denmark since 1 January 2007, there is a shortage of oocyte donors, which is in contrast to the increasing demand from couples in need of donor eggs. In this paper we discuss possibilities to enhance the recruitment of volunteer donors.
View Article and Find Full Text PDFIn September 2003, legislation approved in Denmark legalized work on surplus human embryos from IVF for clinical purposes to establish human embryonic stem (ES) cell cultures. The aim of this study was to establish such stem cell lines. Fresh surplus embryos were donated after informed consent from the donors.
View Article and Find Full Text PDFThe FATE gene maps to Xq28 where one case of a translocation breakpoint has been found in an infertile man. Moreover, the FATE promoter contains a putative SF-1-binding site, and FATE has been proposed as representing a target gene of SF-1 in testicular development or germ cell differentiation. This study presents a complete mutational screening of the FATE gene in a random group of 144 infertile males.
View Article and Find Full Text PDF