Publications by authors named "Karsten P Hug"
Article Synopsis
- Modified balloon angioplasty (MB) and intravascular lithotripsy (IVL) are treatments for in-stent restenosis (ISR), but IVL is currently used off-label in this scenario.
- A study involving 117 patients (36 treated with IVL and 81 with MB) found that IVL resulted in significantly lower residual stenosis compared to MB (2.8% vs. 21.0%).
- Despite the differences in stenosis rates, long-term follow-up showed no significant differences in cardiac death, acute myocardial infarction, or target lesion revascularization between the two treatment groups.
Retention of circulating lipoproteins by their interaction with extracellular matrix molecules has been suggested as an underlying mechanism for atherosclerosis. We investigated the role of glypican-4 (GPC4), a heparan sulfate (HS) proteoglycan, in the development of endothelial dysfunction and plaque progression; Expression of GPC4 and HS was investigated in human umbilical vein/artery endothelial cells (HUVECs/HUAECs) using flow cytometry, qPCR, and immunofluorescent staining. Leukocyte adhesion was determined in HUVECs in bifurcation chamber slides under dynamic flow.
View Article and Find Full Text PDFBackground: Balloon pulmonary angioplasty (BPA) is delivered as a series of treatments for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) however, there is little published data on the procedural determinants of outcome.
Methods: Pre- and post-BPA clinical and hemodynamic data, as well as serial hemodynamic and procedural data at each BPA session were evaluated to determine patient and procedure-related factors that influence hemodynamic response.
Results: Per procedure data from 210 procedures in 84 patients and per patient data from 182 procedures in 63 patients with completed treatment and 3-month follow-up were analyzed.