Publications by authors named "Karsten Kurz"
Article Synopsis
- The study examines the link between high levels of homocysteine and S-adenosylhomocysteine in human bones and how they affect bone quality, focusing on 82 individuals undergoing hip surgery.
- Results show that individuals with elevated bone homocysteine and S-adenosylhomocysteine levels had poorer bone structure, characterized by increased trabecular separation and decreased thickness and area compared to those with lower levels.
- No significant relationship was found between bone morphology and methylation capacity, but a strong correlation was identified between serum and bone homocysteine levels.
Background: Recent clinical and animal studies suggest that increased serum homocysteine (HCY) concentrations may be a risk factor for osteoporosis. In vitro studies showed that increasing HCY concentrations stimulate the activity of human osteoclasts. However, there is no data demonstrating that circulating HCY is related to structural and biomechanical properties of human bones.
View Article and Find Full Text PDFBackground: Several clinical trials have reported B vitamins to be associated with osteoporosis.
Objective: Our objective was to investigate whether low serum B vitamins are associated with altered structural and biomechanical properties of human bone.
Design: Femoral heads of 94 men and women who underwent hip arthroplasty were analyzed by using dual-energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry.