[Ivan Stepanovich Kolesnikov--"general of surgery" (the 110th anniversary of his birth)].

The article is devoted to the 110th anniversary of outstanding surgeon, scientist and educator, academician of the USSR Ivan Stepanovich Kolesnikov. During the Great Patriotic War--he was an army surgeon on the Central Front, and then--in Leningrad. As one of the pioneers of thoracic surgery, the first in the Soviet Union began to apply the resection of pulmonary tuberculosis, cancer, and acute and chronic suppurative diseases of the lung and pleura, reflecting the experience of more than 4,000 thousand operations in numerous monographs and published in 1960, major work, "Resection lights".

[The action of Essentiale and its combination with cordiamine and vitamin E on the processes of xenobiotic biotransformation and lipid peroxidation and on liver structure in rats with cholestasis].

Intensive regeneration of cholangia and cholangioles, fibrosis, microglobular cirrhosis, vacuolar and granular dystrophy, and necrosis of hepatocytes were found in the liver of rats 36 days after ligation of the common bile duct. Lipid peroxidation was activated, the activity of the mono-oxidase system was inhibited in maintained function of glucuro- and glutathione transferase. Essentiale (per os in starch mucilage, 1 ml/kg.