[Using stromal stem cells for the periodontal tissue regeneration and their interaction with tissue microenvironment].

This review paper describes the evolution of the ideas of periodontal tissue regeneration, starting with the concept of selective cellular repopulation, stimulation of resident precursor cells in the regeneration focus, up to the application of versatile potential of the stromal stem cells (SSC). Effects of stem cells isolated from an embryo, bone marrow, and adipose tissue, are described, as well as the immunophenotype of freshly isolated SSC, that of precultured vascular cell fraction as compared with the immunophenotype of SSC cultured during various time periods. The results of the study of the processes of proliferation and cell differentiation of SSC transplanted into the deep periodontal defects, are analyzed using proliferating cell nuclear antigen (PCNA) and green fluorescent protein.

[Perspectives of pharmacological correction of nitroxidergic vasorelaxation in subarachnoidal hemorrhage].

Subarachnoidal hemorrhage (SAH) causes cerebrovascular endothelial dysfunction that leads to impaired nitrosidergic vasorelaxation, delayed vasospasm, and cerebral ischemia. The purpose of the present review is to study the current potentialities of drug action on the system of generation of and the functional activity of nitric oxide (NO) in order to prevent and treat cerebral ischemic complications due to SAH. A scheme of the biosynthesis of NO and the mechanism of nitroxidergic vasorelaxation is presented.

[Changes in the nitrite level of the blood in patients in the acute period of a subarachnoid hemorrhage of aneurysmatic etiology].

Subarachnoidal hemorrhage leads to impaired endothelium-dependent relaxation by inhibiting the synthesis of major vascular relaxation agent nitric oxide (NO). Nitrite, a closest product of the oxidation of NO, is responsible for the synthesis of the latter. The Griss reaction was used for daily measurement of blood nitrite levels in 32 patients with acute subarachnoidal hemorrhage of aneurysmal etiology.