Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs.

Fixed targets are a popular form of sample-delivery system used in serial crystallography at synchrotron and X-ray free-electron laser sources. They offer a wide range of sample-preparation options and are generally easy to use. The supports are typically made from silicon, quartz or polymer.

Thermoplastic Microfluidics.

Thermoplastic polymers are besides glass the material of choice for the industrialization of microfluidic and organ-on-chip applications. In most cases, however, such devices are developed on the basis standard lithographic clean room technologies and subsequent casting into PDMS. This results in comparably fast progress in the development of functional designs but important aspects with respect to later industrialization are thereby largely neglected.

Versatile microporous polymer-based supports for serial macromolecular crystallography.

Serial data collection has emerged as a major tool for data collection at state-of-the-art light sources, such as microfocus beamlines at synchrotrons and X-ray free-electron lasers. Challenging targets, characterized by small crystal sizes, weak diffraction and stringent dose limits, benefit most from these methods. Here, the use of a thin support made of a polymer-based membrane for performing serial data collection or screening experiments is demonstrated.

Surface topology and functionality of freeform microlens arrays.

Nonsymmetric (also known as freeform) optical components have attracted a great deal of academic and industrial attention due to the substantial benefits they have demonstrated in imaging and nonimaging optical systems. Additionally, freeform microlens arrays (FMLAs) are very promising with regard to the growing demand for device miniaturization and cost reduction. As a flip side, FMLAs entail specific challenges in design, manufacturing, and characterization.

Evaluation of Protein Content in the Diet of Amateur Male Bodybuilder.

Public gyms and fitness clubs promote active lifestyles. At the same time, numerous nutritional errors and the phenomenon of incorrect supplementation are being observed among the given study group. Behavior can lead to malaise, injury, or lack of progression.

Electrochemical aptamer-based biosensor developed to monitor PSA and VEGF released by prostate cancer cells.

Early prostate cancer (PCa) diagnostic is crucial to enhance patient survival rates; besides, non-invasive platforms have been developed worldwide in order to precisely detect PCa biomarkers. Therefore, the aim of the present study is to develop a new aptamer-based biosensor through the self-assembling of thiolated aptamers for PSA and VEGF on the top of gold electrodes. This biosensor was tested in three prostate cell lines (RWPE-1, LNCaP and PC3).

Ocular immune reactants in patients dying with systemic lupus erythematosus.

Immunopathologic studies were performed on ocular tissue obtained at autopsy in five patients with systemic lupus erythematosus (SLE). The immunopathologic findings were correlated with histopathologic and clinical features of SLE. Immune reactants were demonstrated by direct immunofluorescence in all patients in a granular pattern suggesting immune complex aggregates; control ocular tissues from four patients without SLE were negative.

[Functional potentials of the microcirculatory system in patients with thrombo-obliterative arterial diseases of the lower extremities].

Photoangiotensiotonography in the microcirculation system was used in order to study hemodynamic indices and its functional potencies in patients with thrombo-obliterating diseases of the lower extremity arteries. The progress of the disease was established to be followed by a considerable decrease of the main indices of hemodynamics in microvessels and the functional capacity of the microcirculation system.

Posterior keratoconus associated with systemic abnormalities.

A 16-year-old girl with bilateral congenital posterior keratoconus of the localized type had corneal transplantation performed on one eye. Around the scarred central corneal cone there was a ring of Descemet's membrane with large knob-like excrescences. A small anterior subcapsular cataract was also present in this eye.

Auditory-visual synesthesia: sound-induced photisms.

Nine patients with visual loss due to lesions of the optic nerve or chiasm experienced photisms induced by sound. Descriptions of these varied from simple flashes of white light to complicated colorful hallucinations likened to a flame, a petal of oscillating lines, a kaleidoscope, or an ameba; they always appeared within a defective portion of the visual field as demonstrated by perimetry. The provoking sounds were usually those of normal daily life, ranged from soft to loud, and always seemed to be heard by the ear ipsilateral to the eye in which the photism was seen.

Corneal transplantation in familial dysautonomia.

A 15-year-old girl with familial dysautonomia had acute corneal ulcerations while on a respiratory during a dysautonomic crisis. Within 18 days she developed irritating corneal ring calcifications. Subsequent corneal perforation in the left eye was treated successfully with a lamellar graft, followed later by a penetrating graft in the right eye under local anesthesia.