Publications by authors named "Karolyn Garcia"
Differences in coloration between the sexes (sexual dichromatism) can increase or decrease in a species through evolutionary changes in either or both sexes diverging or converging in their colors. Few previous studies, however, have examined the relative rates of such changes, particularly when dichromatism is lost. Using reflectance data from 37 species of the New World blackbird family (Icteridae), we compared evolutionary rates of plumage color change in males and females when dichromatism was either increasing (colors diverging) or decreasing (colors converging).
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- * Researchers created a mouse model using CRISPR/Cas9 to study the disease, which mimics characteristics seen in human patients, such as specific gait abnormalities and a reduction in motor skills over time.
- * The Glb1 mice also display progressive brain atrophy and increased levels of a pentasaccharide biomarker, supporting their relevance for developing new treatments for GM1 gangliosidosis, particularly the less severe type II variant.
Article Synopsis
- Protein translation is a complex and tightly controlled process, and its upregulation is linked to conditions like cancer and autism spectrum disorder, though these conditions are not directly correlated.
- In a study of two siblings with genetic mutations in the PUS7 gene, researchers found that both had features of autism and symptoms similar to Lesch-Nyhan syndrome, despite lacking specific variants typically associated with that syndrome.
- The siblings' cell studies showed increased protein synthesis, particularly the MYC protein, yet they did not live through rapid cell growth, highlighting a connection between altered protein translation and neurodevelopmental issues.