Publications by authors named "Karolis Lideikis"
Association of COMT ValMet Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury.
J Neuropsychiatry Clin Neurosci
March 2020
Article Synopsis
- The study explored the link between the COMT gene ValMet polymorphism and the risk of delirium in patients with mild to moderate traumatic brain injury (TBI).
- During the first four days of admission, 19% of the 89 patients developed delirium, with the Val/Val polymorphism significantly increasing delirium risk after adjusting for other variables.
- While the Met allele showed potential for better functional outcomes, it was not significant in multivariable analysis, and delirium itself was a strong predictor of poorer functional and cognitive outcomes.