rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease.

Objective: Oxidative stress plays an important role in Alzheimer's disease (AD) etiopathogenesis. There were several studies that showed impaired antioxidant defense system (ADS) enzymes expression or activity in AD patients. There are only few studies evaluating the importance of ADS gene single nucleotide polymorphisms (SNPs) as risk factors of AD.

A comparison of emotional decoding abilities in patients with amnestic mild cognitive impairment, very mild and mild Alzheimer's disease.

Deficits in emotional decoding abilities were described in patients with Alzheimer's dementia and amnestic type of mild cognitive impairment (a-MCI). However the pattern of decline and its dependency on the type of emotional stimuli has not been investigated so far. In our study, 5 sets of cartoon-like drawings portraying various human emotions of increasing complexity were presented to patients with very mild and mild Alzheimer's dementia, a-MCI and control subjects.

The rs2200733 variant on chromosome 4q25 is a risk factor for cardioembolic stroke related to atrial fibrillation in Polish patients.

Background And Purpose: A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke.

Material And Methods: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.

Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population.

Background And Purpose: Inflammation plays a prominent role in Alzheimer disease (AD) pathogenesis. Interleukin-6 (IL-6), a pro-inflammatory cytokine, and some genetic variations in the IL-6 gene have been reported to be associated with a risk of AD. However, the results of the conducted studies are equivocal.