J Enzyme Inhib Med Chem
December 2023
Schizophrenia is a chronic mental disorder that is not satisfactorily treated with available antipsychotics. The presented study focuses on the search for new antipsychotics by optimising the compound D2AAK3, a multi-target ligand of G-protein-coupled receptors (GPCRs), in particular D, 5-HT, and 5-HT receptors. Such receptor profile may be beneficial for the treatment of schizophrenia.
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April 2023
Schizophrenia is a mental disorder with a complex pathomechanism involving many neurotransmitter systems. Among the currently used antipsychotics, classical drugs acting as dopamine D receptor antagonists, and drugs of a newer generation, the so-called atypical antipsychotics, can be distinguished. The latter are characterized by a multi-target profile of action, affecting, apart from the D receptor, also serotonin receptors, in particular 5-HT and 5-HT.
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