Tackling the challenge of cardiovascular diseases and diabetes across Europe: a joint action by more than 300 public health professionals. Commentary.

Cardiovascular diseases (CVD) and diabetes pose significant health challenges in Europe, affecting millions and burdening healthcare systems. The recent EU4Health Programme places reducing the burden of non-communicable diseases (NCD) at the forefront, through a Joint Action focused on CVD and diabetes (JACARDI, Joint Action on CARdiovascular diseases and DIabetes). This initiative unites 21 European countries, including Ukraine, and over 300 experts.

[Assessment of 24-hour blood pressure function of the single kidney in children with renal agenesis].

Unlabelled: The aim of work was the assessment of the length and function of the single kidney and arterial blood in children with renal agenesis (AN) treated in our Department in 2000-2003 years.

Material And Methods: The examinations were carried out: in 38 children (M--23, F--15) aged 1-16 years (mean 7.6 +/- 5.

Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.

Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly, cells transfected with Bcl-2 were resistant to granzyme B-induced killing, suggesting that a mitochondrial pathway was critical. Utilizing cells expressing a dominant-negative caspase 9, the current study demonstrated that caspase activation via the apoptosome was not required.