Publications by authors named "Karolina Mazurec"
Article Synopsis
- The study investigates the distribution of high-risk HPV types in low and high-grade cervical lesions to understand their role in cervical cancer progression.
- Using data from a large sample of screening tests, the researchers analyzed the prevalence of HPV types and dual staining status among different histological groups.
- Results showed significant differences in HPV 16 prevalence and dual staining positivity between high-grade lesions and lower-grade or negative cases, emphasizing the varying risks associated with cervical lesion grades.
Major screening abnormalities in precolposcopic stage are tests results that imply direct referral to colposcopy (and/or expedited treatment) without performing additional high-grade squamous intraepithelial lesions or worse (HSIL+) risk selection testing. Currently, both clinically validated HSIL+ risk selection tests, reflex cytology and reflex p16/Ki67 dual staining (DS), are being compared for use in primary human papillomavirus (HPV)-based screening to avoid possible overtreatment, but there is still no sufficient data available for their performance. Among 30 066 liquid-based cervical cancer screening tests results, a group of 332 women was selected with available high-risk types of HPV tests results with 16/18 limited genotyping, liquid-based cytology, DS, and histology results from standardized colposcopy with biopsy.
View Article and Find Full Text PDFThe introduction of primary human papillomavirus (HPV) cervical cancer screening requires the implementation of an appropriate triage strategy that will be effective in detecting high-grade cervical disease without losing diagnostic specificity. From the 30.066 screening tests results, a total of 1086 with available high-risk human papillomavirus (HRHPV) with limited genotyping, cytology, and p16/Ki67 dual-stain were selected.
View Article and Find Full Text PDFBackground: In the context of primary HPV cervical cancer screening, the identification of minor screening abnormalities necessitates triage tests to optimize management and mitigate overtreatment. Currently, reflex cytology and reflex p16/Ki67 dual-stain (DS) are under scrutiny for their applicability in primary HPV-based screening. However, there remains a dearth of comprehensive data for comparing their performance.
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- Recent increases in cervical cancer rates among women aged 20-39, especially those 25-29, highlight the need for improved screening in younger populations, even those under 25.
- A study tested three cervical cancer screening methods: primary HRHPV with p16/Ki67 triage, primary cytology with reflex HPV, and primary cytology alone, focusing on women under 30.
- The findings showed that primary HRHPV with p16/Ki67 triage was the most effective in detecting high-grade lesions, suggesting it could serve as a better screening strategy than cytology-based models for younger women.
The baseline data from the private-based opportunistic cervical cancer screening with HRHPV14, liquid-based cytology (LBC) and p16/Ki67 testing, and its quality assessment/quality control (QA/QC) tools are lacking. The age-stratified analysis of 30,066 screening tests results in a Polish population, including the investigation of HRHPV14 status, LBC, and p16/Ki67 dual-staining reporting rates, along with immediate histopathologic correlations, was conducted. For cytopathologic QA/QC, the College of American Pathologists (CAP) benchmarks and enhanced safety protocol were used.
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