Thermally stable biopolymer composites based on poly(3-hydroxybutyrate) modified with linear aliphatic polyurethanes - preparation and properties.

Purpose: Poly(3-hydroxybutyrate) (P3HB) is a biopolymer, but storing products from P3HB causes the deterioration of their properties leading to their brittleness. P3HB has also low thermal stability. Its melting point almost equals its degradation temperature.

Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).

A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20-50%. AmB was in a highly aggregated state with an aggregation ratio often above 2.