Publications by authors named "Karolina Feakins"
Int J Stroke
January 2025
Article Synopsis
- - The Oxford Haemodynamic Adaptation to Reduce Pulsatility (OxHARP) trial studied the effects of sildenafil on cerebrovascular conditions, finding that it increased cerebrovascular reactivity but didn't reduce cerebral pulsatility, both linked to vascular aging.
- - This study aimed to see how the severity of white matter hyperintensities (WMH) relates to both cerebral pulsatility and cerebrovascular reactivity in the same group of patients.
- - Results showed that greater severity of WMH was independently linked to decreased cerebrovascular reactivity and increased cerebral pulsatility, suggesting a complex interaction that warrants further investigation.
Article Synopsis
- * The OxHARP trial included 75 participants with mild-to-moderate brain changes and compared the effects of sildenafil, cilostazol, and a placebo over three weeks using various measures of brain blood flow and function.
- * Results showed that while sildenafil did not change cerebral pulsatility compared to placebo or cilostazol, it did lead to significant increases in blood flow, suggesting some positive effects on cerebrovascular function.
