[Orthostatic tremor - a disregarded diagnosis].

Orthostatic tremor is a rare and often neglected diagnosis with a synchronised bilateral high frequency tremor of 13-18 Hz, affecting primarily the legs and trunk muscles while standing. The patient is troubled by an intense feeling of unsteadiness. Tremor and unsteadiness diminish significantly by sitting down or starting to walk.

Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study.

In advanced stages of Parkinson's disease, serotonergic terminals take up L-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of L-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks L-DOPA-induced dyskinesias in animal models of dopamine depletion, justifying a clinical study with eltoprazine, a 5-HT1A/B receptor agonist, against L-DOPA-induced dyskinesias in patients with Parkinson's disease.