Publications by authors named "Karolin Wieber"
Rheumatoid arthritis (RA) is a chronic rheumatic disease with a clear sex-bias. Recent data indicated a role for dopamine in RA pathogenesis, while dopaminergic pathways can be modulated by estrogens. As defined mechanism of action of dopamine on B cell function in RA are unclear, we aimed to elucidate this, with special focus on sex-differences.
View Article and Find Full Text PDFRecognition of self-peptides in association with distinct HLA class II alleles by autoreactive CD4+ T cells is central for loss of immunological tolerance leading to autoimmune disease. However, identifying immunodominant self-peptides and characterizing autoreactive T cells is challenging. In this issue of the JCI, Falta et al.
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- * Researchers have developed a method to convert human skin fibroblasts into VW-MSCs by using a specific gene code (HOXB7, HOXC6, HOXC8), allowing for this change without going through pluripotency, which is a common step in stem cell research.
- * The induced VW-MSCs demonstrated classical stem cell characteristics, were capable of preventing lymphocyte proliferation, and provided protection against vascular damage in animal models, suggesting these cells might be useful for personalized MSC-based therapies in the future