Publications by authors named "Karolin Streule"
Article Synopsis
- CD44 is a protein that helps cancer cells grow by interacting with another protein called TrkA when a growth factor called NGF is present.
- Scientists found that a specific version of CD44 called CD44v3 is important for this interaction, and they figured out which parts of the proteins are necessary for them to connect.
- They created a special piece of the CD44v3 protein to block this interaction, and it helped stop cancer cells from growing and spreading in experiments.
Acute myeloid leukemia (AML) has a poor prognosis under the current standard of care. In recent years, venetoclax, a BCL-2 inhibitor, was approved to treat patients who are ineligible for intensive induction chemotherapy. However, complete remission rates with venetoclax-based therapies are hampered by minimal residual disease (MRD) in a proportion of patients, leading to relapse.
View Article and Find Full Text PDFMotivation: An automated counting of beads is required for many high-throughput experiments such as studying mimicked bacterial invasion processes. However, state-of-the-art algorithms under- or overestimate the number of beads in low-resolution images. In addition, expert knowledge is needed to adjust parameters.
View Article and Find Full Text PDFThe therapeutic efficacy of the anticancer drug cisplatin is limited by the development of resistance. We therefore investigated newly synthesized platinum-nitroxyl complexes (PNCs) for their potential to circumvent cisplatin resistance. The complexes used were PNCs with bivalent cis-Pt(RNH)(NH)Cl and cis-Pt(DAPO)Ox and four-valent platinum cis,trans,cis-Pt(RNH)(NH)(OR)Cl and cis,trans,cis-Pt(DAPO)(OR)Ox, where R are TEMPO or proxyl nitroxyl radicals, DAPO is trans-3,4-diamino-2,2,6,6-tetramethylpiperidine-1-oxyl, and OR and Ox are carboxylato and oxalato ligands, respectively.
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