In eukaryotes, cellular functions are tightly controlled by diverse post-translational modifications (PTMs) of proteins. One such PTM affecting many proteins is the deimination of arginine to citrulline. This process, called citrullination is catalyzed by a group of hydrolases called protein arginine deiminases (PADs), of which five isoforms have been identified.
View Article and Find Full Text PDFBacteria often express numerous virulence factors. These virulence factors make them successful pathogens, by e.g.
View Article and Find Full Text PDFis one of the main causative agents of nosocomial infections and the spread of multidrug-resistant strains is rising. Therefore, novel strategies for therapy are urgently required. The outer membrane composition of Gram-negative pathogens and especially of restricts the efficacy of antibiotic entry into the cell and determines virulence.
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