Electro-spun Membranes as Scaffolds for Human Corneal Endothelial Cells.

Background: Corneal endothelial dysfunction remains the most frequent indication for corneal transplantation, limited by donor material shortage, poor long-term graft survival, or allogeneic graft rejection. Therefore, tissue-engineered endothelial grafts (TEEG) represent a promising alternative to human donor tissue. In this study, we generated electro-spun scaffolds and tested these for their suitability for human corneal endothelial cell (hCEC) cultivation.

Chlorhexidine Loaded Cyclodextrin Containing PMMA Nanogels as Antimicrobial Coating and Delivery Systems.

Antimicrobial nanogels, aggregates, and films are prepared by complexation of the antiseptic and bacteriostatic agent chlorhexidine (CHX) for medical and dental applications. A series of α-, β-, and γ-cyclodextrin methacrylate (CD-MA) containing hydrophobic poly(methyl methacrylate) (PMMA) based nanogels are loaded quantitatively with CHX in aqueous dispersion. The results show that CHX is enhancedly complexed by the use of CD-MA domains in the particles structure.

Nanogels with high active β-cyclodextrin content as physical coating system with sustained release properties.

We present the application of nanogels with high functional β-cyclodextrin (β-CD) content as new and versatile method for the modification and protection of textiles. The complexation potential of covalently embedded β-CD in nanogels is demonstrated for the common insecticide permethrin in aqueous environment. It is shown that permethrin containing β-CD nanogels can be applied easily, homogeneously and safely on keratin fibers like wool fabrics and human hairs.

Tenside-free preparation of nanogels with high functional β-cyclodextrin content.

We present the preparation of ultrafine (R(h), 50 -150 nm) nanogels through tenside-free condensation of reactive prepolymers with β-cyclodextrin (β-CD) in water. These nanogels possess a maximum content of 60 wt % functional β-CD that can form inclusion complexes as demonstrated by dye sorption with phenolphthalein. Aside of this extremely high uptake capacity to hydrophobic molecules, the nanogels also show good adhesion to surfaces in homogeneous distribution with size of R(h) of 25 nm under dry conditions.