Publications by authors named "Karol Simonji"
Liver fluke infections are acknowledged as diseases with global prevalence and significant implications for both veterinary and public health. The large American liver fluke, , is a significant non-native parasite introduced to Europe, threatening the survival of local wildlife populations. The aim of this study was to analyze differences in the serum proteome and metabolome between -infected and control red deer.
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- Liver fluke infections are significant global health issues for both animals and humans, with concerns about the introduction of the giant liver fluke in Europe threatening local wildlife like red deer.
- The study aimed to compare liver protein profiles between red deer infected with the liver fluke and healthy controls using advanced proteomics techniques, resulting in the identification of 234 proteins that differed in abundance.
- The research found that liver fluke infection in red deer affects various biological processes, including protein and fat metabolism, oxidative stress response, fibrosis, and cell signaling, which helps deepen our understanding of how parasites interact with their hosts.
Article Synopsis
- BPC 157, a stable gastric pentadecapeptide, shows potential in treating major vessel occlusion syndromes by activating collateral pathways and improving venous system function in rats.
- In a study simulating abdominal compartment syndrome, rats receiving BPC 157 had significant recovery from intra-abdominal hypertension and associated complications, including hemorrhagic lesions and brain swelling.
- The treatment prevented serious health issues like severe ECG disturbances, organ congestion, and damage, indicating that BPC 157 effectively cured primary abdominal compartment syndrome.
We redefined Robert's prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar to that which occurs when major central or peripheral veins are occluded in animal models. With this redefinition, we used Robert's model to examine the cytoprotective effects of the stable gastric pentadecapeptide BPC 157. The intragastric administration of alcohol induced gastric lesions, intracranial (superior sagittal sinus) hypertension, severe brain swelling and lesions, portal and vena caval hypertension, aortal hypotension, severe thrombosis, inferior vena cava and superior mesenteric vein congestion, azygos vein failure (as a failed collateral pathway), electrocardiogram disturbances, and heart, lung, liver and kidney lesions.
View Article and Find Full Text PDFPentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419) reversed congestive heart failure and various arrhythmias, influenced the NO-system and showed no proarrhythmic effect. In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i).
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