Publications by authors named "Karol Nga Ieng Chan"
Adv Sci (Weinh)
September 2022
Article Synopsis
- - G protein-coupled receptors (GPCRs) are vital drug targets, yet over 70% are difficult to target with traditional drugs due to their "undruggable" nature.
- - The research introduces small activating RNAs (saRNAs) that can specifically increase the expression of the Mas receptor (MAS1), a GPCR linked to cancer progression.
- - Administered through a specialized delivery system, these saRNAs significantly suppress tumor growth and progression in various cancer models, suggesting a promising new approach to cancer treatment by targeting GPCR signaling.
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