Publications by authors named "Karol Kolkowski"
Article Synopsis
- * The exact cause of vitiligo is not fully understood, but several theories exist, including genetic predisposition and immune system involvement, particularly through T lymphocytes.
- * Recent advancements in treatment options include topical and oral medications like Janus kinase inhibitors and prostaglandins, with ongoing research aiming to develop more effective therapies based on genetic studies.
Article Synopsis
- - Atopic dermatitis (AD) is a complex skin condition with varied symptoms and immune responses, leading to a need for individualized treatment approaches.
- - New therapies, particularly biological drugs and Janus kinase inhibitors, show promise in tailoring treatments based on specific disease characteristics and patient preferences.
- - The article discusses the potential for personalized medicine in AD management, emphasizing the importance of ongoing research to define effective treatment strategies and goals.
Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T-cell lymphoma. GG homozygote rs8193036 A/G of interleukin-17A gene occurred less commonly in the cutaneous T-cell lymphoma group; however, patients with this single-nucleotide polymorphism experience significantly intense pruritus.
View Article and Find Full Text PDFSeasonal Patterns and Trends in Dermatoses in Poland.
Int J Environ Res Public Health
July 2022
Background: The amount of data available online is constantly increasing, including search behavior and tracking trends in domains such as Google. Analyzing the data helps to predict patient needs and epidemiological events more accurately. Our study aimed to identify dermatology-related terms that occur seasonally and any search anomalies during the SARS-CoV-2 pandemic.
View Article and Find Full Text PDFSafety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL).
Postepy Dermatol Alergol
December 2021
Microenvironment has a significant impact on the pathogenesis of cutaneous T-cell lymphoma (CTCL), especially in the context of new emerging biologic therapies. Our aim was to review the literature on interleukins 12, 17, 23 and tumour necrosis factor-α in mycosis fungoides in order to clarify the safety of using biologics in the treatment of psoriasis. Our analysis suggests that these drugs may have an impact on the progression of CTCL.
View Article and Find Full Text PDFArticle Synopsis
- New and emerging therapies like dupilumab and upadacitinib are being explored for their effects on the microenvironment of primary cutaneous lymphomas (PCLs), particularly in patients with atopic dermatitis.
- The study reviews the role of interleukins and JAK/STAT pathways in PCLs to assess the safety of biologics and small molecule inhibitors used in treatment.
- Results indicate that some therapies may impact cutaneous lymphoma progression, warranting close patient monitoring and the need for biopsies in rapidly worsening cases, especially for those over 40.