The phytochemical piceatannol induces the loss of CBL and CBL-associated proteins.

Piceatannol is a naturally occurring bioactive stilbene with documented antileukemic properties. It has been extensively used as a Syk-selective protein tyrosine kinase inhibitor for the study of various signaling pathways. Herein, we show that the hydroxystilbene, piceatannol, and related catechol ring-containing compounds are able to induce the loss of the Cbl family of proteins.

Derivatives of substituted 3-trichlorogermylpropionic acid.

The central Ge atoms in the structures of 3-(2-fluorophenyl)-3-(triphenylgermyl)propionic acid, [Ge(C(6)H(5))(3)(C(9)H(8)FO(2))], 3-(2-tolyl)-3-(tri-4-tolylgermyl)propionic acid, [Ge(C(7)H(7))(3)(C(10)H(11)O(2))], and 3-(4-tolyl)-3-(tribenzylgermyl)propionic acid, [Ge(C(7)H(7))(3)(C(10)H(11)O(2))], are four-coordinate with slightly distorted tetrahedral geometry. The Ge-Csp(3) distances [1.970 (3)-1.