[Control of myocardial ischemia in patients with effort angina and polyvascular atherosclerotic involvement].

In patients with ischemic heart disease with various degree of severity of atherosclerotic involvement of peripheral arteries maintenance of target levels of arterial pressure and heart rate with the help of therapy which includes cardioselective -adrenoblocker as a preparation of choice with addition if necessary of a calcium antagonist and angiotensin converting enzyme inhibitor allows to successfully control myocardial ischemia and heart rate under conditions of everyday life.

Education by a nurse increases response of patients with chronic hepatitis C to therapy with peginterferon-α2a and ribavirin.

Background & Aims: Education of patients with chronic hepatitis C has been proposed to increase response to therapy with peginterferon and ribavirin. We performed a prospective study to determine the effects of systematic consultation by a nurse on patient adherence and the efficacy of therapy.

Methods: We analyzed data from 244 patients who received either systematic consultation after each medical visit from a nurse who used a standard evaluation grid and provided information about the disease and treatment (group A [GrA], n = 123) or the conventional clinical follow-up procedure (group B [GrB], n = 121).

[Late diagnosis of celiac disease].

A 45 year-old woman presented with late-diagnosed celiac disease, marked disorders of calcium and bone metabolism, and severe osteoporosis. Weak enteral symptoms delayed diagnosis. High efficiency of agluten and vitamin D therapy was documented.

[Methylenebisphosphonic acid alters the pattern of pericellular glycosaminoglycans and binding properties of CD44 in human endothelial cells].

The effect of methylenebisphosphonic acid (MBPA) on glycosaminoglycan metabolism, adhesive and proliferative properties of human endothelial cells has been investigated. It was demonstrated that MBPA (100 microM) inhibited the synthesis of all studied groups of glycosaminoglycans, but promoted the accumulation of heparan sulphate in endothelial pericellular matrix. Simultaneously, the redistribution of hyaluronic acid from pericellular matrix to the conditioned medium was observed.

[Radiation diagnosis of involutional osteopenia].

160 patients with involutive osteopaenia were investigated. The diagnostic possibilities of roentgenography, magnetic resonance imaging and computed tomography were evaluated. There was determined that roentgenography gives the possibility to determine the common localisation and the expressiveness of the pathologic process.

[The morphofunctional characteristics of the duodenum in an osteopenic syndrome in children and adolescents].

Aim: The study of duodenal morphology in children and adolescents with skeletal deformity.

Materials And Methods: Clinical, hormonal examinations, x-ray investigation of the skeleton with spinal NMR-tomography, gastroduodenoscopy with target biopsy were performed in 41 patients aged 7 to 18 on after treatment for broken spine.

Results: Atrophic duodenitis found in most of the patients presented without dyspepsia, with symptoms of duodenitis in 8 patients, osteoporosis in 36% of patients.

[Department of molecular immunology].

The Department of Molecular Immunology was created at the Institute in 1982. It was founded by S. V.

[Osteomalacia and its development in patients after stomach resection].

An examination was performed in 15 patients who had developed pronounced osteomalacia following gastric resection. The discussion covers potential pathogenetic mechanisms responsible for bone tissue metabolism disorders and approaches to correction thereof.

[Osteopathy in malabsorption syndromes].

Electrolytic imbalance is a frequent finding in malabsorption syndrome. Derangement of calcium metabolism present clinically in different variants is most serious. Some patients develop hypocalcemia manifesting clinically with specific myasthenia, paresthesias, convulsions, hemorrhages, etc.

[Inorganic pyrophosphatase activity of the mouse spleen in the immune response and after treatment with bis-phosphonates].

The inorganic pyrophosphatase activity was determined in different tissues of mice. The immunization of mice by sheep erythrocytes increased the inorganic pyrophosphatase activity of the spleen. The in vivo administration of bisphosphonates (40 mg per 1 g of mass), which are structural analogs of inorganic pyrophosphate (methylene bisphosphonic acid--MBPA, hydroxyethylidene bisphosphonic acid--HEBPA and aminomethylene bisphosphonic acid--AMBPA), inhibited the inorganic pyrophosphatase activity only by MBPA in the thymus and spleen but not in liver.

[Effect of methylene diphosphonic acid on certain processes in animal tissues].

It was shown that methylene diphosphonic acid, a structural analogue of pyrophosphate, exhibiting immunodepressant properties, in a dose of 40 micrograms/g body weight inhibits by 20% the activity of inorganic pyrophosphatase in the spleen of BALB mice and does not affect this enzyme in the liver or thymus. In noninbred albino mice inhibition of the activity of the enzyme was recorded only as a result of administering the preparation in a dose of 80 micrograms/g. Histological data on the kidneys, liver, lungs, spleen, lymphatic nodes and thymus indicate that the preparation does not exert a significant toxic action on the body.

[Diagnostic value of the system of Frank's orthogonal leads in inveterate myocardial infarct].

Comparison of data obtained in recording corrected orthogonal leads of the Frank system and 12 classical ECG leads in 118 patients with ischemic heart disease, among whom there were 76 patients with an old myocardial infarction, showed that corrected orthogonal leads may be used in mass population survey with the use of automatic diagnostic machines. It was established that the following ECG indices may be used in recording Frank's corrected orthogonal leads in the diagnosis of cicatricial myocardial changes: amplitude and duration of Q wave, the Q/R and R/S coefficients, the appearance of wave S in lead "Z". In an old myocardial infarction of posterior localization changes are recorded in lead "Y", in infarction of antero-septal localization changes are recorded in lead "Z" and to a lesser degree in lead "X"; in infarction of antero-lateral localization changes are recorded in lead "X" and to a lesser degree in lead "Z".