Publications by authors named "Karlotta A Fitch"
Article Synopsis
- Oxidative stress is linked to the development of Alzheimer's disease (AD), and higher dietary antioxidants like carotenoids and tocopherols may help protect cognitive function and reduce AD risk.
- This study aimed to determine if levels of these micronutrients are significantly lower in brains of individuals with AD compared to healthy elderly individuals.
- The findings revealed that AD brains had much lower levels of several important antioxidants (lutein, zeaxanthin, etc.) but showed elevated levels of a mysterious metabolite (XMiAD), suggesting a complex relationship between antioxidants and AD.
Background: Pathological hallmarks of Alzheimer's disease include cerebral beta-amyloid (Abeta) deposition, amyloid accumulation, and neuritic plaque formation. We aimed to investigate the hypothesis that molecular pathological findings associated with Alzheimer's disease overlap in the lens and brain.
Methods: We obtained postmortem specimens of eyes and brain from nine individuals with Alzheimer's disease and eight controls without the disorder, and samples of primary aqueous humour from three people without the disorder who were undergoing cataract surgery.