Publications by authors named "Karlo Jambrosic"
Article Synopsis
- - A study assessed the presence and distribution of 43 pharmaceutical compounds (PhACs) in the Sava River (Croatia) focusing on their potential to bioaccumulate in fish and the environmental risks associated with this.
- - Utilizing a specific LC-MS/MS method, researchers found that PhAC residues varied significantly between water and fish samples, with major antibiotics rising in prevalence near wastewater discharge areas, while upstream, psychostimulants and opioids were common.
- - The study highlighted varying bioconcentration factors (BCFs) of PhACs in different fish tissues, with some compounds showing moderate to moderately high BCFs, indicating their significance for environmental risk assessments, particularly with the influence of biotransformation processes.
In this work, a wide-scope liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of environmental levels of multiclass drugs and their metabolites in water and fish samples was developed. The method allowed the reliable determination of 44 drugs, covering a rather wide range of chemistries and physicochemical characteristics. In order to obtain a reliable and robust analytical protocol, different combinations of extraction and cleanup techniques were systematically examined.
View Article and Find Full Text PDFToll-like receptors (TLRs), as a family of pattern recognition receptors, play an important role in the recognition of HIV-1 molecular structures by various cells of the innate immune system, but also provide a functional association with subsequent mechanisms of adaptive immunity. TLR7 and TLR8 play a particularly important role in the innate immune response to RNA viruses due to their ability to recognise GU-rich single-stranded RNA molecules and subsequently activate intracellular signalling pathways resulting in expression of genes coding for various biological response modifiers (interferons, proinflammatory cytokines, chemokines). The aim of this review is to summarise the most recent knowledge on the role of TLRs in the innate immune response to HIV-1 and the role of TLR gene polymorphisms in the biology and in the clinical aspects of HIV infections.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) was discovered in 1964 in the cell line of Burkitt lymphoma and became first known human oncogenic virus. EBV belongs to the family, and is present worldwide as it infects 95% of people. Infection with EBV usually happens during childhood when it remains asymptomatic; however, in adults, it can cause an acute infection known as infectious mononucleosis.
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