Publications by authors named "Karlijn M C Cornel"
Article Synopsis
- Patients with high-grade endometrial carcinoma (EC) have a higher likelihood of tumor spread and lymph node metastasis (LNM), with preoperative imaging and CA125 levels aiding in their assessment.
- A study involving 333 high-grade EC patients found that elevated CA125 levels significantly correlated with advanced disease stages and poorer survival outcomes.
- Logistic regression analysis indicated that elevated CA125, non-endometrioid histology, deep myometrial invasion, and cervical involvement are strong predictors of LNM, while CT findings alone were less predictive.
Objective: To investigate whether a previously performed endometrial ablation is associated with the development and diagnosis of endometrial cancer.
Methods: First, a systematic review was performed of the articles reporting the incidence of endometrial cancer in patients treated with endometrial ablation. Second, a systematic review was performed to identify all individual cases of endometrial cancer after ablation to evaluate presenting symptoms, diagnostic work-up, potential risk factors, and the type and stage of the endometrial cancer.
Up to 60% of untreated atypical hyperplastic endometrium will develop into endometrial carcinoma (EC), and for those who underwent a hysterectomy a coexisting EC is found in up to 50%. Gene promoter methylation might be related to the EC development. The aim of this study is to determine changes in gene promoter profiles in normal endometrium, atypical hyperplasia (AH) and EC in relation to K-Ras mutations.
View Article and Find Full Text PDFMost endometrial cancers (ECs) are diagnosed at an early stage and have a good prognosis. However, 20-30% develop recurrence and have poor survival. Recurrence-risk prediction at diagnosis is hampered by the scarcity of prognostic markers.
View Article and Find Full Text PDFContext: The local interconversions between estrone (low activity) and 17β-estradiol (potent compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high 17β-estradiol generation in endometrial cancer (EC).
Objective: Examine the balance between the 17β-HSDs reducing estrone to 17β-estradiol (types 1, 5, 12, and 7) and those oxidizing 17β-estradiol to estrone (2, 4, and 8), in EC.
Patients And Methods: Reducing and oxidizing 17β-HSD activities (HPLC) and mRNA level (RT-PCR) were assessed in normal post-menopausal (n = 16), peritumoral endometrium (normal tissue beside cancer, n = 13), and 58 EC (29 grade 1, 18 grade 2, 11 grade 3).